Miniature ambulatory skin conductance monitor and algorithm for investigating hot flash events.
Miniature ambulatory skin conductance monitor and algorithm for investigating hot flash events.
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DOI：
10.1088/0967-3334/35/2/95
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发表时间：
2014-02
影响因子：
3.2
通讯作者：
Zhou X
中科院分区：
文献类型：
--
作者：
Bahr DE;Webster JG;Grady D;Kronenberg F;Creasman J;Macer J;Shults M;Tyler M;Zhou X
开发了一种皮肤电导监测系统，该系统在有监督的实验室和无监督的流动条件下都能可靠地采集和记录潮热事件。7.2 cm × 3.8 cm × 1.2 cm监护仪由支持两个水凝胶电极的一次性贴片和可重复使用的小型化封闭电子电路板组成，该电路板卡在电极上。监测仪在没有外部电线或遥测的情况下测量并记录皮肤电导七天，并且具有事件标记，受试者可以在经历热潮红时按下该事件标记。通过将本研究期间开发的算法检测到的潮热数量与潮热研究专家确定的数量进行比较，证明了该系统的准确性。评估了三种检测热闪事件的方法，但只有两种方法得到充分开发。这两个被开发的人工神经网络和匹配滤波器技术与多个内核实现为滑动形式的皮尔逊积矩相关系数。这两种算法都在17名女性的“发展”队列中进行了训练，然后使用第二个类似的20名“验证”队列进行验证。所有受试者的年龄在40至60岁之间，并且自我报告在三天内每天有10次或更多的潮热。匹配滤波器是最准确的，使用来自开发队列的数据，平均灵敏度为0.92，平均特异性为0.90，使用来自验证队列的数据，平均灵敏度为0.92，平均特异性为0.87。匹配滤波器是在我们的处理软件中实现的方法。
A skin conductance monitoring system was developed and shown to reliably acquire and record hot flash events in both supervised laboratory and unsupervised ambulatory conditions. The 7.2 cm × 3.8 cm × 1.2 cm monitor consists of a disposable adhesive patch supporting two hydrogel electrodes and a reusable, miniaturized, enclosed electronic circuit board that snaps onto the electrodes. The monitor measures and records the skin conductance for seven days without external wires or telemetry and has an event marker that the subject can press whenever a hot flash is experienced. The accuracy of the system was demonstrated by comparing the number of hot flashes detected by algorithms developed during this research with the number identified by experts in hot flash studies. Three methods of detecting hot flash events were evaluated, but only two were fully developed. The two that were developed were an Artificial Neural Network and a Matched Filter technique with multiple kernels implemented as a sliding form of the Pearson Product-Moment Correlation Coefficient. Both algorithms were trained on a “development” cohort of 17 women and then validated using a second similar “validation” cohort of 20. All subjects were between the ages of 40 and 60 and self-reported 10 or more hot flashes per day over a three day period. The Matched Filter was the most accurate with a mean sensitivity of 0.92 and a mean specificity of 0.90 using the data from the development cohort and a mean sensitivity of 0.92 and a mean specificity of 0.87 using the data from the validation cohort. The Matched Filter was the method implemented in our processing software.
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DOI：
10.1097/gme.0b013e31823dbbe3
发表时间：
2012-06
期刊：
Menopause (New York, N.Y.)
影响因子：
--
作者：
Carpenter JS;Newton KM;Sternfeld B;Joffe H;Reed SD;Ensrud KE;Milata JL
通讯作者：
Milata JL
影响因子：
45.3
作者：
Sloan, JA;Loprinzi, CL;Windschitl, H
通讯作者：
Windschitl, H
影响因子：
7.2
作者：
Carpenter, JS;Monahan, PO
通讯作者：
Monahan, PO
DOI：
10.1097/gme.0b013e3181f7a17a
发表时间：
2011-04
期刊：
Menopause (New York, N.Y.)
影响因子：
--
作者：
Low DA;Hubing KA;Del Coso J;Crandall CG
通讯作者：
Crandall CG
影响因子：
6.7
作者：
Freedman, Robert R.;Wasson, Samuel
通讯作者：
Wasson, Samuel