Mechanisms of cutaneous vasodilation during the postmenopausal hot flash.
Mechanisms of cutaneous vasodilation during the postmenopausal hot flash.
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DOI：
10.1097/gme.0b013e3181f7a17a
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Crandall CG
中科院分区：
文献类型：
--
作者：
Low DA;Hubing KA;Del Coso J;Crandall CG
更年期潮热会严重扰乱有症状的女性的生活。潮热传出反应的生理机制，特别是在皮肤循环中，还没有完全了解。这项研究的目的是研究有症状的妇女在绝经后潮热期间皮肤血流量增加的机制。健康的绝经后妇女在体温控制的实验室休息，而潮热前和潮热期间的反应被记录为三种独特的方案。方案1和方案2：妇女在前臂(方案1)和眉间区域(方案2)局部皮内注射A型肉毒杆菌毒素(BTX；阻断交感胆碱能神经的神经递质释放)。方案3：记录来自腓神经的皮肤交感神经活动，以及由该神经信号支配的区域内的皮肤血流量和出汗。使用激光多普勒血流计对BTX治疗和邻近未治疗对照部位的皮肤血流量进行指标化。潮热的开始被客观地确定为胸骨出汗率的一过性和显著的升高。潮热期间前臂抬高(方案1)和肩周炎皮肤血流量(方案2)在BTX部位相对于邻近未治疗部位减弱(P<；两种方案均为0.05)。在方案3中，皮肤交感神经活动在潮热期间显著增加，并在潮热后恢复到潮热前的水平。绝经后潮热时皮肤血流量的升高主要是通过BTX敏感神经，可能是交感胆碱能神经调节的。
Menopausal hot flashes can seriously disrupt the lives of symptomatic women. The physiological mechanisms of the hot flash efferent responses, particularly in the cutaneous circulation, are not completely understood. The aim of this study was to examine the mechanisms of increases in skin blood flow during the postmenopausal hot flash in symptomatic women. Healthy postmenopausal women rested in a temperature controlled laboratory while responses prior to and during hot flashes were recorded for three unique protocols. Protocols 1 and 2: Women were locally pretreated with an intradermal injection of botulinum toxin A (BTX; blocks the release of neurotransmitters from sympathetic cholinergic nerves) in the forearm (protocol 1) and in the glabellar region (protocol 2). Protocol 3: Skin sympathetic nerve activity from the peroneal nerve was recorded, along with skin blood flow and sweating within the region innervated by that neural signal. Skin blood flow was indexed using laser-Doppler flowmetry at BTX-treated and adjacent untreated control sites. The onset of a hot flash was objectively identified as a transient and pronounced elevation of sternal sweat rate. The elevation in forearm (protocol 1) and glabellar skin blood flow (protocol 2) during hot flashes were attenuated at BTX sites relative to adjacent untreated sites (P<0.05 for both protocols). In protocol 3, skin sympathetic nerve activity significantly increased during hot flashes and returned to pre-flash levels following the hot flashes. Elevations in skin blood flow during the postmenopausal hot flash are neurally mediated primarily through BTX sensitive nerves; presumably sympathetic cholinergic.
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DOI：
10.1097/gme.0b013e3181d674d6
发表时间：
2010-09
期刊：
Menopause (New York, N.Y.)
影响因子：
--
作者：
Hubing KA;Wingo JE;Brothers RM;Del Coso J;Low DA;Crandall CG
通讯作者：
Crandall CG
DOI：
10.1111/j.1471-0528.1981.tb02230.x
发表时间：
1981-01-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
GINSBURG, J;SWINHOE, J;OREILLY, B
通讯作者：
OREILLY, B
DOI：
10.1097/gme.0b013e3180ca7cfa
发表时间：
2008-03-01
影响因子：
2.7
作者：
Low, David A.;Davis, Scott L.;Crandall, Craig G.
通讯作者：
Crandall, Craig G.
影响因子：
5.5
作者：
BINI, G;HAGBARTH, KE;WALLIN, BG
通讯作者：
WALLIN, BG
影响因子：
3.9
作者：
KRONENBERG, F
通讯作者：
KRONENBERG, F