Theoretical Schemas to Guide Back Pain Consortium (BACPAC) Chronic Low Back Pain Clinical Research.
Theoretical Schemas to Guide Back Pain Consortium (BACPAC) Chronic Low Back Pain Clinical Research.
复制标题
指导腰背痛联盟(BACPAC)慢性下腰痛临床研究的理论方案。
DOI：
10.1093/pm/pnac196
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发表时间：
2023-08-04
期刊：
影响因子：
3.1
通讯作者：
Lotz, Jeffrey
中科院分区：
文献类型：
--
作者：
Chau, Anthony;Steib, Sharis;Whitaker, Evans;Kohns, David;Quinter, Alexander;Craig, Anita;Chiodo, Anthony;Chandran, SriKrishan;Laidlaw, Ann;Schott, Zachary;Farlow, Nathan;Yarjanian, John;Omwanghe, Ashley;Wasserman, Ronald;O'Neill, Conor;Clauw, Dan;Bowden, Anton;Marras, William;Carey, Tim;Mehling, Wolf;Hunt, C. Anthony;Lotz, Jeffrey
慢性下腰痛（cLBP）是一种复杂的异质性临床表现。需要更好地了解导致cLBP的因素，以便准确诊断，最佳治疗和识别新疗法的机制靶点。背部疼痛联盟（BACPAC）研究计划在这方面提供了一个独特的机会，因为它将生成大型临床数据集，包括一组不同的协调测量。成立了理论模型工作组，以指导BACPAC研究，并在机械框架内组织新知识。本文总结了理论模型工作组的初步工作。它包括三个阶段的专家意见和影响cLBP严重程度和慢性化因素的文献综述。在第一阶段，来自BACPAC的专家建立了风险和预后因素（RPF）的分类法和初步的图形解释。在第2阶段，一个单独的团队根据系统性综述和荟萃分析的首选报告项目（PRISMA）指南进行了文献综述，以确定工作定义、相关数据元素和已识别RPF的总体证据强度。这些意见随后在第三阶段与专家意见结合起来。大多数（约80%）RPF的证据强度置信度很低，而7个因素与cLBP（疼痛相关焦虑、血清C反应蛋白、糖尿病和预期/代偿性姿势调整）呈正相关或与cLBP无相关（血清白细胞介素1-β/白细胞介素6、横肌形态/活动和定量感觉测试）具有实质性置信度。这种理论观点将随着时间的推移而发展，因为BACPAC研究人员将经验结果与理论联系起来，挑战生物心理社会模型的当前想法，并使用系统方法开发工具和算法，以解开cLBP因素之间的动态相互作用。
Chronic low back pain (cLBP) is a complex with a heterogenous clinical presentation. A better understanding of the factors that contribute to cLBP is needed for accurate diagnosis, optimal treatment, and identification of mechanistic targets for new therapies. The Back Pain Consortium (BACPAC) Research Program provides a unique opportunity in this regard, as it will generate large clinical datasets, including a diverse set of harmonized measurements. The Theoretical Model Working Group was established to guide BACPAC research and to organize new knowledge within a mechanistic framework. This article summarizes the initial work of the Theoretical Model Working Group. It includes a three-stage integration of expert opinion and an umbrella literature review of factors that affect cLBP severity and chronicity. During Stage 1, experts from across BACPAC established a taxonomy for risk and prognostic factors (RPFs) and preliminary graphical depictions. During Stage 2, a separate team conducted a literature review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to establish working definitions, associated data elements, and overall strength of evidence for identified RPFs. These were subsequently integrated with expert opinion during Stage 3. The majority (∼80%) of RPFs had little strength-of-evidence confidence, whereas seven factors had substantial confidence for either a positive association with cLBP (pain-related anxiety, serum C-reactive protein, diabetes, and anticipatory/compensatory postural adjustments) or no association with cLBP (serum interleukin 1-beta / interleukin 6, transversus muscle morphology/activity, and quantitative sensory testing). This theoretical perspective will evolve over time as BACPAC investigators link empirical results to theory, challenge current ideas of the biopsychosocial model, and use a systems approach to develop tools and algorithms that disentangle the dynamic interactions among cLBP factors.
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与腰痛和活动限制的敏捷性变化相关：系统文献综述和荟萃分析。
影响因子：
3.7
作者：
Herlin C;Kjaer P;Espeland A;Skouen JS;Leboeuf-Yde C;Karppinen J;Niinimäki J;Sørensen JS;Storheim K;Jensen TS
通讯作者：
Jensen TS
影响因子：
2
作者：
Cormack, Ben;Stilwell, Peter;Gibson, Jo
通讯作者：
Gibson, Jo
影响因子：
1.6
作者：
Corns, Jennifer
通讯作者：
Corns, Jennifer
DOI：
10.1080/20476965.2022.2029584
发表时间：
2023
期刊：
Health systems (Basingstoke, England)
影响因子：
--
作者：
通讯作者：
--
影响因子：
4
作者：
Bojcic R;Todoric M;Puljak L
通讯作者：
Puljak L