Vagus nerve spiking activity associated with locomotion and cortical arousal states in a freely moving rat
Vagus nerve spiking activity associated with locomotion and cortical arousal states in a freely moving rat
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与自由移动大鼠的运动和皮质唤醒状态相关的迷走神经尖峰活动
DOI：
10.1111/ejn.14275
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发表时间：
2018
影响因子：
3.4
通讯作者：
Takuya Sasaki
中科院分区：
文献类型：
--
作者：
Yu Shikano;Yuya Nishimura;Toya Okonogi;Yuji Ikegaya;Takuya Sasaki
迷走神经是中枢和外周器官之间交流的中枢通路。尽管传统知识的迷走神经功能，迷走神经在naïve行为的详细神经生理动力学仍有待了解。在这项研究中，我们开发了一种新的方法来记录颈部迷走神经的尖峰模式，同时监测自由运动大鼠的中枢和外周器官的生物电信号。当运动活动短暂升高时，迷走神经尖峰的频率相应增加，且这种活动在跑步速度增加结束后仍保持数秒。迷走神经的尖峰模式与动物进入高架迷宫的哪只手臂没有明显的联系。在嗅探行为中，迷走神经刺几乎不存在。在停止过程中，迷走神经脉冲模式根据外部环境和与皮层唤醒水平相关的外周活动状态而有很大差异。迷走神经的刺激改变了大鼠的跑步速度和皮层的觉醒状态，这取决于刺激瞬间的跑步速度。这些观察结果为揭示迷走神经调节内脏器官（如心血管、呼吸和胃肠道系统）的生理动力学迈出了新的一步。
The vagus nerve serves as a central pathway for communication between the central and peripheral organs. Despite traditional knowledge of vagus nerve functions, detailed neurophysiological dynamics of the vagus nerve in naïve behavior remain to be understood. In this study, we developed a new method to record spiking patterns from the cervical vagus nerve while simultaneously monitoring central and peripheral organ bioelectrical signals in a freely moving rat. When the rats transiently elevated locomotor activity, the frequency of vagus nerve spikes was correspondingly increased, and this activity was retained for several seconds after the increase in running speed terminated. Spike patterns of the vagus nerve were not robustly associated with which arms the animals entered on an elevated plus maze. During sniffing behavior, vagus nerve spikes were nearly absent. During stopping, the vagus nerve spike patterns differed considerably depending on external contexts and peripheral activity states associated with cortical arousal levels. Stimulation of the vagus nerve altered rat's running speed and cortical arousal states depending on running speed at the instant of stimulation. These observations are a new step for uncovering the physiological dynamics of the vagus nerve modulating the visceral organs such as cardiovascular, respiratory, and gastrointestinal systems.
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