The spatial distribution of actin and mechanical cycle of myosin are different in right and left ventricles of healthy mouse hearts.
The spatial distribution of actin and mechanical cycle of myosin are different in right and left ventricles of healthy mouse hearts.
复制标题
肌动蛋白的空间分布和肌球蛋白的机械循环在健康小鼠心脏的左右心室不同。
DOI：
10.1021/bi501175s
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发表时间：
2014-12-09
期刊：
影响因子：
2.9
通讯作者：
Borejdo, J.
中科院分区：
文献类型：
--
作者：
Nagwekar, J.;Duggal, D.;Rich, R.;Raut, S.;Fudala, R.;Gryczynski, I.;Gryczynski, Z.;Borejdo, J.
右心室（RV）的收缩将血液排入肺循环，左心室（LV）的收缩将血液通过主动脉泵入体循环。由主动脉和肺动脉压力施加在LV和RV上的各自后负荷对两个心室产生非常不同的机械要求。事实上，已经观察到扩张型心肌病、充血性心力衰竭中左心室和右心室肌细胞之间的收缩性能存在差异，以及健康心脏在轻负荷下的能量使用和收缩速度存在差异。尽管存在这些功能差异，但通常认为右心室和左心室肌肉是相同的，因为犬RV和LV之间的应激发展、抽搐持续时间、工作性能或功率没有差异。这份报告表明，在介观尺度上[当只研究离体心室肌原纤维中的几个分子（这里是三到六个肌动蛋白分子）时]，僵硬状态下的两个心室在微丝内和跨桥循环动力学收缩过程中肌动蛋白取向紊乱的程度不同。
The contraction of the right ventricle (RV) expels blood into the pulmonary circulation, and the contraction of the left ventricle (LV) pumps blood into the systemic circulation through the aorta. The respective afterloads imposed on the LV and RV by aortic and pulmonary artery pressures create very different mechanical requirements for the two ventricles. Indeed, differences have been observed in the contractile performance between left and right ventricular myocytes in dilated cardiomyopathy, in congestive heart failure, and in energy usage and speed of contraction at light loads in healthy hearts. In spite of these functional differences, it is commonly believed that the right and left ventricular muscles are identical because there were no differences in stress development, twitch duration, work performance, or power among the RV and LV in dogs. This report shows that on a mesoscopic scale [when only a few molecules are studied (here three to six molecules of actin) in ex vivo ventricular myofibrils], the two ventricles in rigor differ in the degree of orientational disorder of actin within in filaments and during contraction in the kinetics of the cross-bridge cycle.
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影响因子：
2.9
作者：
Mettikolla, P.;Calander, N.;Luchowski, P.;Gryczynski, I.;Gryczynski, Z.;Borejdo, J.
通讯作者：
Borejdo, J.
影响因子：
3.4
作者：
Barman, T;Brune, M;Webb, MR
通讯作者：
Webb, MR
影响因子：
3.4
作者：
Hopkins, SC;Sabido-David, C;Goldman, YE
通讯作者：
Goldman, YE
影响因子：
3.4
作者：
Cadete, Virgilio J. J.;Lin, Han-bin;Sawicki, Grzegorz
通讯作者：
Sawicki, Grzegorz
DOI：
10.1152/ajpheart.00942.2011
发表时间：
2012-02-01
影响因子：
4.8
作者：
Carlsson, M.;Heiberg, E.;Arheden, H.
通讯作者：
Arheden, H.