Prevalence and acquisition of the genes for zoocin A and zoocin A resistance in Streptococcus equi subsp. zooepidemicus.
Prevalence and acquisition of the genes for zoocin A and zoocin A resistance in Streptococcus equi subsp. zooepidemicus.
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DOI：
10.1007/s00239-009-9221-x
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发表时间：
2009-05
影响因子：
3.9
通讯作者：
Simmonds, Robin S.
中科院分区：
文献类型：
--
作者：
Gargis, Amy S.;O'Rourke, Anna-Lee D.;Sloan, Gary L.;Simmonds, Robin S.
动物凝集素A是由马链球菌亚种产生的一种链球菌裂解酶。动物疫霉4881株。ZooA基因(ZooA)和指定对zoocin A的抗性的基因(ZIF)在染色体上相邻，并以不同的方式转录。24个马链霉菌亚种。分析了3株动物疫霉素A产生菌(4881、9G和9H)与21株非产生菌之间的遗传差异。LT-PCR和Southern杂交研究表明，非产生菌中没有一株含有ZooA或ZIF。RAPD和PFGE分析表明，这24个菌株是一个遗传多样性群体，具有8条随机扩增多态性DNA图谱。[中英文摘要]马链霉属S.9G株和9H株在基因上似乎是相同的，但与4881株有很大的不同。来自4881和9G的序列表明，ZooA和ZIF整合到了与FLAR基因相邻的染色体上。将这些序列与马链霉菌基因组序列进行了比较。兽疫菌株H70、MGCS10565和马链霉菌亚种。Equi菌株4047表明，FLAR位于该物种基因组可塑性的侧翼。
Zoocin A is a streptococcolytic enzyme produced by Streptococcus equi subsp. zooepidemicus strain 4881. The zoocin A gene (zooA) and the gene specifying resistance to zoocin A (zif) are adjacent on the chromosome and are divergently transcribed. Twenty-four S. equi subsp. zooepidemicus strains were analyzed to determine the genetic difference between three previously characterized as zoocin A producers (strains 4881, 9g and 9h) and the twenty-one non-producers. LT-PCR and Southern hybridization studies revealed that none of the non-producer strains possessed zooA or zif. RAPD and PFGE showed that the 24 strains were a genetically diverse population with 8 RAPD profiles. S. equi subsp. zooepidemicus strains 9g and 9h appeared genetically identical to each other, but quite different from 4881. Sequences derived from 4881 and 9g showed that zooA and zif were integrated into the chromosome adjacent to the gene flaR. A comparison of these sequences with the genome sequences of S. equi subsp. zooepidemicus strains H70 and MGCS10565 and S. equi subsp. equi strain 4047 suggests that flaR flanks a region of genome plasticity in this species.
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影响因子：
3.7
作者：
Beres SB;Sesso R;Pinto SW;Hoe NP;Porcella SF;Deleo FR;Musser JM
通讯作者：
Musser JM
影响因子：
3
作者：
Bert, F;Picard, B;LambertZechovsky, N
通讯作者：
LambertZechovsky, N
DOI：
10.1099/00207713-45-4-693
发表时间：
1995-10-01
期刊：
INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY
影响因子：
--
作者：
KEIS, S;BENNETT, CF;JONES, DT
通讯作者：
JONES, DT
影响因子：
9.4
作者：
TENOVER, FC;ARBEIT, RD;SWAMINATHAN, B
通讯作者：
SWAMINATHAN, B
影响因子：
4.4
作者：
Beukes, M;Hastings, JW
通讯作者：
Hastings, JW