XeNA: an automated 'open-source' (129)Xe hyperpolarizer for clinical use.
XeNA: an automated 'open-source' (129)Xe hyperpolarizer for clinical use.
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DOI：
10.1016/j.mri.2014.02.002
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发表时间：
2014-06
影响因子：
2.5
通讯作者：
Goodson, Boyd M.
中科院分区：
文献类型：
--
作者：
Nikolaou, Panayiotis;Coffey, Aaron M.;Walkup, Laura L.;Gust, Brogan M.;Whiting, Nicholas;Newton, Hayley;Muradyan, Iga;Dabaghyan, Mikayel;Ranta, Kaili;Moroz, Gregory D.;Rosen, Matthew S.;Patz, Samuel;Barlow, Michael J.;Chekmenev, Eduard Y.;Goodson, Boyd M.
在这里，我们提供了关于我们联盟的用于临床、临床前和材料NMR/MRI的“开源”大规模（~1 L/hr）129 μ π ι超极化器的构造、组件和能力的完整报告（Nikolaou等人，Proc. Natl. Acad. Sci. USA，110，14150（2013））。“超偏振器”是自动化的，主要由现成的组件组成;此外，它的设计具有成本效益，安装在研究实验室和临床环境中，材料成本低于125，000美元。该设备运行在氙丰富的制度（高达1800托在0.5升），无论是停止流动或单批模式，使超极化气体的低温收集不必要的许多应用。在~300-1600 Torr的质子负载下，测得电池内129欧姆核的自旋极化值为~30-90%。在我们的SEOP条件下，典型的129 Ω极化建立和T1弛豫时间常数分别为~8.5 min和~1.9 hr;这样的比率，结合由高共振激光功率（高达~200 W）实现的接近1的Rb电子自旋极化，允许实现如此高的PtR值，尽管单元内的PtR密度很高。重要的是，大部分极化在高效HP气体转移到其他容器期间保持，并且在运输到临床3 T扫描仪进行MR光谱和成像作为体内实验的前奏后，在Tedlar袋中观察到超长的129 μ m弛豫时间（长达近6小时）。该器械已获得FDA IND批准，用于COPD受试者的临床研究。本文的主要重点是偏振器的技术/工程开发，明确的目标是促进适应其他实验室的设计功能和操作模式，并促进HP-气体MR在生物医学中的应用的进一步发展。
Here we provide a full report on the construction, components, and capabilities of our consortium’s “open-source” large-scale (~1 L/hr) 129Xe hyperpolarizer for clinical, pre-clinical, and materials NMR/MRI (Nikolaou et al., Proc. Natl. Acad. Sci. USA, 110, 14150 (2013)). The ‘hyperpolarizer’ is automated and built mostly of off-the-shelf components; moreover, it is designed to be cost-effective and installed in both research laboratories and clinical settings with materials costing less than $125,000. The device runs in the xenon-rich regime (up to 1800 Torr Xe in 0.5 L) in either stopped-flow or single-batch mode—making cryo-collection of the hyperpolarized gas unnecessary for many applications. In-cell 129Xe nuclear spin polarization values of ~30-90% have been measured for Xe loadings of ~300-1600 Torr. Typical 129Xe polarization build-up and T1 relaxation time constants were ~8.5 min and ~1.9 hr respectively under our SEOP conditions; such ratios, combined with near-unity Rb electron spin polarizations enabled by the high resonant laser power (up to ~200 W), permits such high PXe values to be achieved despite the high in-cell Xe densities. Importantly, most of the polarization is maintained during efficient HP gas transfer to other containers, and ultra-long 129Xe relaxation times (up to nearly 6 hr) were observed in Tedlar bags following transport to a clinical 3 T scanner for MR spectroscopy and imaging as a prelude to in vivo experiments. The device has received FDA IND approval for a clinical study of COPD subjects. The primary focus of this paper is on the technical / engineering development of the polarizer, with the explicit goals of facilitating the adaptation of design features and operative modes into other laboratories, and of spurring the further advancement of HP-gas MR applications in biomedicine.
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影响因子：
2.2
作者：
Coffey, Aaron M.;Shchepin, Roman V.;Chekmenev, Eduard Y.
通讯作者：
Chekmenev, Eduard Y.
影响因子：
64.8
作者：
ALBERT, MS;CATES, GD;WISHNIA, A
通讯作者：
WISHNIA, A
影响因子：
3.3
作者：
Kaushik, S. Sivaram;Cleveland, Zackary I.;Cofer, Gary P.;Metz, Gregory;Beaver, Denise;Nouls, John;Kraft, Monica;Auffermann, William;Wolber, Jan;McAdams, H. Page;Driehuys, Bastiaan
通讯作者：
Driehuys, Bastiaan
影响因子：
3.7
作者：
Lilburn DM;Hughes-Riley T;Six JS;Stupic KF;Shaw DE;Pavlovskaya GE;Meersmann T
通讯作者：
Meersmann T
影响因子：
4.4
作者：
Cleveland, ZI;Pavlovskaya, GE;Meersmann, T
通讯作者：
Meersmann, T