Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease.
Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease.
复制标题
DOI：
10.1002/mrm.22697
复制
发表时间：
2011-04
影响因子：
3.3
通讯作者：
Driehuys, Bastiaan
中科院分区：
文献类型：
--
作者：
Kaushik, S. Sivaram;Cleveland, Zackary I.;Cofer, Gary P.;Metz, Gregory;Beaver, Denise;Nouls, John;Kraft, Monica;Auffermann, William;Wolber, Jan;McAdams, H. Page;Driehuys, Bastiaan
关键词：
129Xe表观扩散系数(ADC)磁共振成像提供了一种替代3He ADC MRI的方法，因为它具有更高的可用性和更低的成本。为了证明HP 129Xe ADC磁共振成像的可行性，我们提供了来自健康志愿者(HV)、慢性阻塞性肺疾病(COPD)受试者和年龄匹配的健康对照(AMC)的结果。高血压组、肺气肿组和肺气肿组的平均ADC值分别为0.036±0.003 cm2/S、0.043±0.006 cm2/S和0.056±0.008 cm2/S。在健康个体中，但不是慢性阻塞性肺疾病组，前后方向的ADC值显著降低约22%(p=0.006，AMC；0.0059，HV)，这可能是由于重力引起的组织压缩。慢性阻塞性肺疾病组上下ADC值减少(~28%)明显大于健康组(~24%)(p=0.00018 HV；p=3.45x10-5AMC)，与吸烟相关的上肺组织破坏一致。健康受试者的上-下梯度可能是由于氙气浓度的地区差异造成的。ADC值与肺功能指标呈正相关(FEV1，r=-0.77，p=0.0002；FEV1/FVC，r=-0.78，p=0.0002；DLco/VA，r=-0.77，p=0.0002)；健康组随年龄增长，ADC值增加0.0002 cm~2/FVC/a(r=0.56，p=0.02)。这项研究表明，129Xe ADC MRI在临床上是可行的，足够敏感地区分HV和肺气肿患者，并检测年龄和体位依赖性的变化。
129Xe apparent diffusion coefficient (ADC) MRI offers an alternative to 3He ADC MRI, given its greater availability and lower cost. To demonstrate the feasibility of HP 129Xe ADC MRI, we present results from healthy volunteers (HV), chronic obstructive pulmonary disease (COPD) subjects, and age-matched healthy controls (AMC). The mean parenchymal ADC was 0.036±0.003 cm2/s for HV, 0.043±0.006 cm2/s for AMC, and 0.056±0.008 cm2/s for COPD subjects with emphysema. In healthy individuals, but not the COPD group, ADC decreased significantly in the anterior-posterior direction by ~22% (p = 0.006, AMC; 0.0059, HV), likely due to gravity-induced tissue compression. The COPD group exhibited a significantly larger superior-inferior ADC reduction (~28%) than the healthy groups (~24%) (p = 0.00018 HV; p = 3.45×10-5 AMC), consistent with smoking-related tissue destruction in the superior lung. Superior-inferior gradients in healthy subjects may result from regional differences in xenon concentration. ADC was significantly correlated with pulmonary function tests (FEV1, r=-0.77, p=0.0002; FEV1/FVC, r=-0.78, p=0.0002; DLCO/VA, r=-0.77, p=0.0002), and in healthy groups, increased with age by 0.0002 cm2/s/yr (r=0.56, p=0.02). This study shows 129Xe ADC MRI is clinically feasible, sufficiently sensitive to distinguish HV from subjects with emphysema, and detects age and posture-dependent changes.
登录
查看更多内容
影响因子：
4.8
作者：
Fain, SB;Altes, TA;Owers-Bradley, J
通讯作者：
Owers-Bradley, J
影响因子：
3.3
作者：
Mugler, JP;Driehuys, B;Wagshul, ME
通讯作者：
Wagshul, ME
影响因子：
3.3
作者：
Diaz, Sandra;Casselbrant, Ingrid;Akeson, Per
通讯作者：
Akeson, Per
DOI：
10.1002/jmri.1880070314
发表时间：
1997-05-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
Kauczor, HU;Ebert, M;Thelen, M
通讯作者：
Thelen, M
影响因子：
3.3
作者：
Holmes, James H.;O'Halloran, Rafael L.;Fain, Sean B.
通讯作者：
Fain, Sean B.