No Evidence of Induced Skin Cancer or Other Skin Abnormalities after Long-Term (66 week) Chronic Exposure to 222-nm Far-UVC Radiation.
No Evidence of Induced Skin Cancer or Other Skin Abnormalities after Long-Term (66 week) Chronic Exposure to 222-nm Far-UVC Radiation.
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DOI：
10.1111/php.13656
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发表时间：
2023-01
影响因子：
3.3
通讯作者：
Brenner, David J.
中科院分区：
文献类型：
--
作者：
Welch, David;Kleiman, Norman J.;Arden, Peter C.;Kuryla, Christine L.;Buonanno, Manuela;Ponnaiya, Brian;Wu, Xuefeng;Brenner, David J.
远紫外线辐射，通常被定义为200-235 nm，与传统的254 nm杀菌辐射相比，具有类似或更强的抗微生物效果。此外，远UVC与组织相互作用的生物物理考虑，以及在动物模型和人类中进行的多项短期安全性研究表明，远UVC暴露对皮肤和眼睛组织可能是安全的。然而，长期接触远紫外线后患皮肤癌的可能性还没有被研究过。在这里，我们评估了96只SKH-1无毛小鼠的致癌皮肤变化和其他病理皮肤异常，这些小鼠无论性别，都接受了平均每天400、130或55 mJ cm−2 222 nm远紫外线照射66 周、每周5 天、每天8 h的背部皮肤剂量，以及类似处理的非暴露对照组。在远紫外线暴露的小鼠中，没有观察到皮肤癌增加、皮肤异常生长或偶然的皮肤病理发现的证据。此外，发病率或死亡率没有显著变化。这项研究的结果支持长期长期暴露在远UVC辐射下的长期安全性，因此它作为一种实用的抗微生物方法在室内环境中减少空气传播的病毒和细菌负载具有潜在的适用性。我们评估了96只SKH-1无毛小鼠的致癌皮肤变化和其他病理皮肤异常，这些小鼠无论性别，都接受了平均每天400 、130 或55 MJ cm−2 222 nm远紫外线照射66 周、每周5 天、每天8 h的远紫外线照射，以及类似处理的非暴露对照组。在远紫外线暴露的小鼠中，没有观察到皮肤癌增加、皮肤异常生长或偶然的皮肤病理发现的证据。这项研究的发现支持长期长期暴露在远紫外线辐射下的长期安全性。
Far‐UVC radiation, typically defined as 200–235 nm, has similar or greater anti‐microbial efficacy compared with conventional 254‐nm germicidal radiation. In addition, biophysical considerations of the interaction of far‐UVC with tissue, as well as multiple short‐term safety studies in animal models and humans, suggest that far‐UVC exposure may be safe for skin and eye tissue. Nevertheless, the potential for skin cancer after chronic long‐term exposure to far‐UVC has not been studied. Here, we assessed far‐UVC induced carcinogenic skin changes and other pathological dermal abnormalities in 96 SKH‐1 hairless mice of both sexes that were exposed to average daily dorsal skin doses of 400, 130 or 55 mJ cm−2 of 222 nm far‐UVC radiation for 66 weeks, 5 days per week, 8 h per day, as well as similarly‐treated unexposed controls. No evidence for increased skin cancer, abnormal skin growths or incidental skin pathology findings was observed in the far‐UVC‐exposed mice. In addition, there were no significant changes in morbidity or mortality. The findings from this study support the long‐term safety of long‐term chronic exposure to far‐UVC radiation, and therefore its potential suitability as a practical anti‐microbial approach to reduce airborne viral and bacterial loads in occupied indoor settings. We assessed far‐UVC‐induced carcinogenic skin changes and other pathological dermal abnormalities in 96 SKH‐1 hairless mice of both sexes that were exposed to average daily dorsal skin doses of 400 , 130 or 55 mJ cm−2 of 222 nm far‐UVC radiation for 66 weeks, 5 days per week, 8 h per day, as well as similarly treated unexposed controls. No evidence for increased skin cancer, abnormal skin growths or incidental skin pathology findings was observed in the far‐UVC‐exposed mice. The findings from this study support the long‐term safety of long‐term chronic exposure to far‐UVC radiation.
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影响因子：
4.6
作者：
Buchan AG;Yang L;Atkinson KD
通讯作者：
Atkinson KD
影响因子：
4.6
作者：
Eadie E;Hiwar W;Fletcher L;Tidswell E;O'Mahoney P;Buonanno M;Welch D;Adamson CS;Brenner DJ;Noakes C;Wood K
通讯作者：
Wood K
影响因子：
5
作者：
Elso, CM;Roberts, LJ;Handman, E
通讯作者：
Handman, E
影响因子：
1.8
作者：
Agresti, A;Coull, BA
通讯作者：
Coull, BA
影响因子：
3.7
作者：
Buonanno M;Randers-Pehrson G;Bigelow AW;Trivedi S;Lowy FD;Spotnitz HM;Hammer SM;Brenner DJ
通讯作者：
Brenner DJ