Far-UVC (222 nm) efficiently inactivates an airborne pathogen in a room-sized chamber.
Far-UVC (222 nm) efficiently inactivates an airborne pathogen in a room-sized chamber.
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DOI：
10.1038/s41598-022-08462-z
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发表时间：
2022-03-23
影响因子：
4.6
通讯作者：
Wood K
中科院分区：
文献类型：
--
作者：
Eadie E;Hiwar W;Fletcher L;Tidswell E;O'Mahoney P;Buonanno M;Welch D;Adamson CS;Brenner DJ;Noakes C;Wood K
包括COVID-19在内的许多传染病都是通过空气传播的病原体传播的。有必要采取有效的环境控制措施，这些措施最好不依赖于人类行为。一种潜在的解决方案是氯化氪（KrCl）准分子灯（通常称为远紫外线），它可以有效地灭活空气中的病原体，例如冠状病毒和流感。研究表明，当KrCl灯被过滤以去除较长波长的紫外线辐射时，它们不会引起皮肤或眼睛的急性反应，也不会引起皮肤癌等延迟效应。虽然有实验室证据证明远紫外线的功效，但在全尺寸房间中的证据有限。这是第一次，我们表明，远紫外线部署在一个房间大小的腔室有效地灭活雾化金黄色葡萄球菌。在房间通风率为每小时3次换气（ACH）时，使用5个过滤源，稳态病原体负荷减少了98.4%，提供了额外的184次等效换气（eACH）。这种减少是使用远紫外线辐照度与目前的美国政府工业卫生学家会议的阈值限制值皮肤连续8小时曝光一致。我们的数据表明，远紫外线可能更有效地对抗常见的空气传播病毒，包括SARS-CoV-2，而不是细菌，因此应该是一种有效的和“不干涉”的技术，以减少空气传播疾病的传播。研究结果提供了房间规模的数据，以支持有效的远紫外线系统的设计和开发。
Many infectious diseases, including COVID-19, are transmitted by airborne pathogens. There is a need for effective environmental control measures which, ideally, are not reliant on human behaviour. One potential solution is Krypton Chloride (KrCl) excimer lamps (often referred to as Far-UVC), which can efficiently inactivate pathogens, such as coronaviruses and influenza, in air. Research demonstrates that when KrCl lamps are filtered to remove longer-wavelength ultraviolet emissions they do not induce acute reactions in the skin or eyes, nor delayed effects such as skin cancer. While there is laboratory evidence for Far-UVC efficacy, there is limited evidence in full-sized rooms. For the first time, we show that Far-UVC deployed in a room-sized chamber effectively inactivates aerosolised Staphylococcus aureus. At a room ventilation rate of 3 air-changes-per-hour (ACH), with 5 filtered-sources the steady-state pathogen load was reduced by 98.4% providing an additional 184 equivalent air changes (eACH). This reduction was achieved using Far-UVC irradiances consistent with current American Conference of Governmental Industrial Hygienists threshold limit values for skin for a continuous 8-h exposure. Our data indicate that Far-UVC is likely to be more effective against common airborne viruses, including SARS-CoV-2, than bacteria and should thus be an effective and “hands-off” technology to reduce airborne disease transmission. The findings provide room-scale data to support the design and development of effective Far-UVC systems.
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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DOI：
10.1016/s0140-6736(21)00869-2
发表时间：
2021-05-01
期刊：
Lancet (London, England)
影响因子：
--
作者：
Greenhalgh T;Jimenez JL;Prather KA;Tufekci Z;Fisman D;Schooley R
通讯作者：
Schooley R
影响因子：
3.3
作者：
Kaidzu S;Sugihara K;Sasaki M;Nishiaki A;Ohashi H;Igarashi T;Tanito M
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