Evolutionary insights into postembryonic development of adult intestinal stem cells.
Evolutionary insights into postembryonic development of adult intestinal stem cells.
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DOI：
10.1186/2045-3701-1-37
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发表时间：
2011-11-16
影响因子：
7.5
通讯作者：
Shi YB
中科院分区：
文献类型：
--
作者：
Ishizuya-Oka A;Shi YB
在成年脊椎动物的肠道中，多能干细胞在整个成年期持续产生所有的上皮细胞。虽然人们早就知道青蛙的肠道是通过甲状腺激素（TH）依赖性变态过程中成体肠道干细胞的发育形成的，但成年肠道的基本结构是由哺乳动物出生时形成的，目前还不清楚肠道的后续成熟是否涉及肠道干细胞的任何变化。最近的两篇论文表明，B淋巴细胞诱导的成熟蛋白1（Blimp 1）调节出生后上皮干细胞在小鼠肠道成熟过程中的重编程支持的模型，成年肠道干细胞在哺乳动物胚胎后发育过程中，在TH依赖的过程中类似于两栖动物变态期间的肠道重塑。由于在哺乳动物和两栖动物中成体肠道的形成与内源性TH水平的峰值期间从水生生物到陆生生物的适应密切相关，因此成体干细胞发育的分子机制可能在进化上保守。
In the adult vertebrate intestine, multi-potent stem cells continuously generate all of the epithelial cells throughout the adulthood. While it has long been known that the frog intestine is formed via the development of adult intestinal stem cells during thyroid hormone (TH)-dependent metamorphosis, the basic structure of the adult intestine is formed by birth in mammals and it is unclear if the subsequent maturation of the intestine involves any changes in the intestinal stem cells. Two recent papers showing that B lymphocyte-induced maturation protein 1 (Blimp1) regulates postnatal epithelial stem cell reprogramming during mouse intestinal maturation support the model that adult intestinal stem cells are developed during postembryonic development in mammals, in a TH-dependent process similar to intestinal remodeling during amphibian metamorphosis. Since the formation of the adult intestine in both mammals and amphibians is closely associated with the adaptation from aquatic to terrestrial life during the peak of endogenous TH levels, the molecular mechanisms by which the adult stem cells are developed are likely evolutionally conserved.
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DOI：
10.1126/science.1180794
发表时间：
2010-01-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Li L;Clevers H
通讯作者：
Clevers H
影响因子：
12.3
作者：
Heimeier RA;Das B;Buchholz DR;Fiorentino M;Shi YB
通讯作者：
Shi YB
影响因子：
5.2
作者：
Matsuda, Hiroki;Shi, Yun-Bo
通讯作者：
Shi, Yun-Bo
影响因子：
16.6
作者：
通讯作者：
--
影响因子：
7.5
作者：
Shi YB;Hasebe T;Fu L;Fujimoto K;Ishizuya-Oka A
通讯作者：
Ishizuya-Oka A