Blimp1 regulates the transition of neonatal to adult intestinal epithelium.
Blimp1 regulates the transition of neonatal to adult intestinal epithelium.
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DOI：
10.1038/ncomms1463
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发表时间：
2011-08-30
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
在许多哺乳动物物种中，肠道上皮发生重大变化，使哺乳期结束时的饮食从母乳过渡到成人饮食。这些复杂的发育变化是肠道固有的遗传程序的结果，但其调节因子尚未确定。在这里，我们表明，转录抑制因子B淋巴细胞诱导的成熟蛋白1（Blimp 1）是高度表达的发展和出生后的肠上皮细胞，直到哺乳到断奶的过渡。肠道特异性Blimp1缺失导致生长迟缓和新生儿死亡率过高突变小鼠缺乏哺乳期的所有典型上皮特征，出生时具有成人样肠道的特征。我们的结论是，哺乳期断奶的过渡是由一个单一的转录抑制因子，延迟上皮成熟。许多哺乳动物出生时就有不成熟的肠上皮，在断奶期间适应不断变化的饮食。Muncan等人表明，转录抑制因子Blimp 1在出生时在小鼠的肠道中表达，并且在过渡到断奶阶段时表达丧失。
In many mammalian species, the intestinal epithelium undergoes major changes that allow a dietary transition from mother's milk to the adult diet at the end of the suckling period. These complex developmental changes are the result of a genetic programme intrinsic to the gut tube, but its regulators have not been identified. Here we show that transcriptional repressor B lymphocyte-induced maturation protein 1 (Blimp1) is highly expressed in the developing and postnatal intestinal epithelium until the suckling to weaning transition. Intestine-specific deletion of Blimp1 results in growth retardation and excessive neonatal mortality. Mutant mice lack all of the typical epithelial features of the suckling period and are born with features of an adult-like intestine. We conclude that the suckling to weaning transition is regulated by a single transcriptional repressor that delays epithelial maturation. Many mammals are born with an immature intestinal epithelium, which adapts to a changing diet during the weaning period. Muncan et al. show that the transcriptional repressor Blimp1 is expressed in the intestine of mice at birth, and that expression is lost at the transition to the weaning stage.
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影响因子：
--
作者：
CALVERT, R;POTHIER, P
通讯作者：
POTHIER, P
影响因子：
21.3
作者：
Ancelin, Katia;Lange, Ulrike C.;Surani, M. Azim
通讯作者：
Surani, M. Azim
影响因子：
7
作者：
Hansson, Jenny;Panchaud, Alexandre;Kussmann, Martin
通讯作者：
Kussmann, Martin
影响因子：
3.6
作者：
HENNING, SJ;GUERIN, DM
通讯作者：
GUERIN, DM
DOI：
10.1083/jcb.108.4.1187
发表时间：
1989-04
期刊：
The Journal of cell biology
影响因子：
--
作者：
Gordon JI
通讯作者：
Gordon JI