Different Associations of Trunk and Lower-Body Fat Mass Distribution with Cardiometabolic Risk Factors between Healthy Middle-Aged Men and Women.
Different Associations of Trunk and Lower-Body Fat Mass Distribution with Cardiometabolic Risk Factors between Healthy Middle-Aged Men and Women.
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健康中年男性和女性躯干和下半身脂肪量分布与心脏代谢危险因素的不同关联
DOI：
10.1155/2018/1289485
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发表时间：
2018
影响因子：
2.8
通讯作者：
Kazumi T
中科院分区：
文献类型：
--
作者：
Wu B;Huang J;Fukuo K;Suzuki K;Yoshino G;Kazumi T
本研究的目的是评估脂肪量（FM）分布的性别特异性模式是否与心脏代谢危险因素的性别差异有关。207名健康的中年日本人被纳入研究。我们用双能X线吸收法（DXA）测量全身、躯干和下半身的FM。躯干FM（TFM）和下半身FM（LFM）的百分比分别记为%TFM和%LFM。其他测量包括口服葡萄糖耐量试验（OGTT）期间的葡萄糖和胰岛素、瘦素、脂联素、纤溶酶原激活物抑制剂-1（派-1）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）和全身氧化应激标志物。以心踝血管指数（CAVI）和颈总动脉内膜中层厚度（IMT）来表示动脉特性。结果表明，男性的%TFM高于女性，而%LFM低于女性，男性具有更强的致动脉粥样硬化性心脏代谢特征。在两种性别中，%TFM（%LFM）与不利（有利）的心脏代谢特征相关。特别是，%LFM和OGTT衍生的胰岛素敏感性指数之间的关系在女性中比男性更强。这些结果表明，在相对健康的成年人，男性和女性样的FM分布模式有助于心脏代谢危险因素的性别差异。
The aim of this study was to assess whether the gender-specific pattern of fat mass (FM) distribution is related to gender differences in cardiometabolic risk factors. 207 healthy middle-aged Japanese were included in the study. We measured FM in the total body, trunk, and lower-body with dual-energy X-ray absorptiometry (DXA). The percentage of trunk FM (TFM) and lower-body FM (LFM) is noted as %TFM and %LFM, respectively. Other measurements included glucose and insulin during oral glucose tolerance test (OGTT), leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and systemic oxidative stress marker. Arterial properties were indicated by cardio-ankle vascular index (CAVI) and intima-media thickness (IMT) of the common carotid artery. The results showed that %TFM is higher whereas %LFM is lower in men than in women and men have a more atherogenic cardiometabolic profile. In both genders, %TFM (%LFM) is related to an unfavorable (favorable) cardiometabolic profile. In particular, the relation between %LFM and OGTT-derived insulin sensitivity index is stronger in women than in men. These findings suggested that in relatively healthy adults, android and gynoid pattern of FM distribution contributes to gender differences in cardiometabolic risk factors.
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DOI：
10.1038/oby.2005.206
发表时间：
2005-10-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Kantartzis, K;Fritsche, A;Stefan, N
通讯作者：
Stefan, N
DOI：
10.1152/ajpendo.00203.2004
发表时间：
2005-02-01
影响因子：
5.1
作者：
Kabir, M;Catalano, KJ;Bergman, RN
通讯作者：
Bergman, RN
影响因子：
7.1
作者：
BORKAN, GA;GERZOF, SG;SILBERT, JE
通讯作者：
SILBERT, JE
影响因子：
9.8
作者：
Miljkovic-Gacic, Iva;Wang, Xiaojing;Zmuda, Joseph M.
通讯作者：
Zmuda, Joseph M.
影响因子：
168.9
作者：
MEADE, TW;RUDDOCK, V;MILLER, GJ
通讯作者：
MILLER, GJ