Rethinking m(6)A Readers, Writers, and Erasers.
Rethinking m(6)A Readers, Writers, and Erasers.
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DOI：
10.1146/annurev-cellbio-100616-060758
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发表时间：
2017-10-06
影响因子：
11.3
通讯作者：
Jaffrey SR
中科院分区：
文献类型：
--
作者：
Meyer KD;Jaffrey SR
近年来，m6A已成为整个转录组中丰富且动态调节的修饰。最近的技术进步使m6A残基的转录组范围内的识别，这反过来又提供了重要的见解，这种普遍的监管标志物的生物学和监管。我们目前对m6A的理解也很重要，这就是m6A阅读器、写入器和擦除器的发现和表征。在过去的几年里，对这些蛋白质功能的研究已经导致了关于m6A的调节和功能的重要发现。然而，在这段时间里，我们对这些蛋白质的理解也发生了相当大的变化，有时会导致关于m6A的阅读、写入和擦除的早期概念的逆转。在这篇综述中，我们总结了m6A研究的最新进展，并强调了这些新发现如何重塑了我们对m6A在转录组中如何调控的理解。
In recent years, m6A has emerged as an abundant and dynamically regulated modification throughout the transcriptome. Recent technological advances have enabled the transcriptome-wide identification of m6A residues, which in turn has provided important insights into the biology and regulation of this pervasive regulatory mark. Also central to our current understanding of m6A are the discovery and characterization of m6A readers, writers, and erasers. Over the last few years, studies into the function of these proteins have led to important discoveries about the regulation and function of m6A. However, during this time our understanding of these proteins has also evolved considerably, sometimes leading to the reversal of early conceptions regarding the reading, writing and erasing of m6A. In this review, we summarize recent advances in m6A research, and we highlight how these new findings have reshaped our understanding of how m6A is regulated in the transcriptome.
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影响因子：
6.7
作者：
Gokhale NS;Horner SM
通讯作者：
Horner SM
YTHDF2 通过直接招募 CCR4-NOT 去腺苷酶复合物来破坏含有 m(6)A 的 RNA 的稳定性。
影响因子：
16.6
作者：
Du, Hao;Zhao, Ya;He, Jinqiu;Zhang, Yao;Xi, Hairui;Liu, Mofang;Ma, Jinbiao;Wu, Ligang
通讯作者：
Wu, Ligang
影响因子：
23.9
作者：
Batista, Pedro J.;Molinie, Benoit;Wang, Jinkai;Qu, Kun;Zhang, Jiajing;Li, Lingjie;Bouley, Donna M.;Lujan, Ernesto;Haddad, Bahareh;Daneshvar, Kaveh;Carter, Ava C.;Flynn, Ryan A.;Zhou, Chan;Lim, Kok-Seong;Dedon, Peter;Wernig, Marius;Mullen, Alan C.;Xing, Yi;Giallourakis, Cosmas C.;Chang, Howard Y.
通讯作者：
Chang, Howard Y.
影响因子：
11.4
作者：
Fawcett, Katherine A.;Barroso, Ines
通讯作者：
Barroso, Ines
DOI：
10.1007/s004380050292
发表时间：
1996-11-27
期刊：
MOLECULAR AND GENERAL GENETICS
影响因子：
--
作者：
Granadino, B;Penalva, LOF;Sanchez, L
通讯作者：
Sanchez, L