The genetics of obesity: FTO leads the way.
The genetics of obesity: FTO leads the way.
复制标题
DOI：
10.1016/j.tig.2010.02.006
复制
发表时间：
2010-06
影响因子：
11.4
通讯作者：
Barroso, Ines
中科院分区：
文献类型：
--
作者：
Fawcett, Katherine A.;Barroso, Ines
2007年，在多个人群中发现了脂肪质量和肥胖相关(FTO)基因区域的单核苷酸多态(SNPs)与体重指数(BMI)和肥胖风险的关联，使FTO成为第一个明确与肥胖相关的基因座。当时，FTO是一个功能未知的基因，也不知道这些SNP是否通过影响FTO或邻近基因而对肥胖产生影响。因此，这一突破性的关联激发了大量的电子、体外和体内分析，以提高对FTO功能的认识。这些研究表明，FTO在控制摄食行为和能量消耗方面起着作用。在这里，我们回顾了为研究其他肥胖相关基因提供蓝图所采取的方法，希望这一策略将导致对体重调节背后的生物学机制的更多了解。
In 2007, an association of single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) gene region with body mass index (BMI) and risk of obesity was identified in multiple populations, making FTO the first locus unequivocally associated with adiposity. At the time, FTO was a gene of unknown function and it was not known whether these SNPs exerted their effect on adiposity by affecting FTO or neighboring genes. Therefore, this breakthrough association inspired a wealth of in silico, in vitro, and in vivo analyses in model organisms and humans to improve knowledge of FTO function. These studies suggested that FTO plays a role in controlling feeding behavior and energy expenditure. Here, we review the approaches taken that provide a blueprint for the study of other obesity-associated genes in the hope that this strategy will result in increased understanding of the biological mechanisms underlying body weight regulation.
登录
查看更多内容
影响因子：
158.5
作者：
Cecil, Joanne E.;Tavendale, Roger;Palmer, Colin N. A.
通讯作者：
Palmer, Colin N. A.
影响因子：
7.7
作者：
Freathy RM;Timpson NJ;Lawlor DA;Pouta A;Ben-Shlomo Y;Ruokonen A;Ebrahim S;Shields B;Zeggini E;Weedon MN;Lindgren CM;Lango H;Melzer D;Ferrucci L;Paolisso G;Neville MJ;Karpe F;Palmer CN;Morris AD;Elliott P;Jarvelin MR;Smith GD;McCarthy MI;Hattersley AT;Frayling TM
通讯作者：
Frayling TM
影响因子：
9.3
作者：
Al-Attar SA;Pollex RL;Ban MR;Young TK;Bjerregaard P;Anand SS;Yusuf S;Zinman B;Harris SB;Hanley AJ;Connelly PW;Huff MW;Hegele RA
通讯作者：
Hegele RA
影响因子：
7.1
作者：
Bauer, Florianne;Elbers, Clara C.;van der Schouw, Yvonne T.
通讯作者：
van der Schouw, Yvonne T.
影响因子：
5.8
作者：
Hakanen, Maarit;Raitakari, Olli T.;Ronnemaa, Tapani
通讯作者：
Ronnemaa, Tapani