Atrial natriuretic peptide and type 2 diabetes development--biomarker and genotype association study.
Atrial natriuretic peptide and type 2 diabetes development--biomarker and genotype association study.
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DOI：
10.1371/journal.pone.0089201
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Magnusson M
中科院分区：
文献类型：
--
作者：
Jujić A;Nilsson PM;Engström G;Hedblad B;Melander O;Magnusson M
我们最近发现，血浆中区域心钠素(MR-ANP)的低水平可以预测糖尿病的发展和血糖随时间的进展，独立于糖尿病发生的已知危险因素。然而，由于MR-ANP水平可能受到引起糖尿病的未知因素的影响，我们不能排除这种关系可能是混淆的。以前的研究表明，利钠肽前体A(NPPA)基因上的单核苷酸多态性rs5068与循环ANP水平较高有关。由于基因变异是随机遗传的，不受混淆的影响，我们的目的是调查NPPA基因座内的变异rs5068是否与2型糖尿病相关。我们对来自MalmöDiet癌症研究的27,307名非糖尿病患者的NPPA基因座内的rs5068变异进行了基因分型。糖尿病事件通过国家和地区登记(14年的中位数随访时间，2823例糖尿病事件)进行检索。在调整年龄、性别和体重指数的COX回归分析中，我们发现携带至少一个G等位基因的人在14年内发生糖尿病的可能性较低(HR = 为0.88，95%CI为0.78~0.99，p = 为0.037)。我们的结果表明心钠素系统在2型糖尿病的病因学中的作用，并可能有助于深入了解利钠肽的代谢作用和2型糖尿病的病理生理。
We have recently shown that low plasma levels of mid-regional atrial natriuretic peptide (MR-ANP) predict development of diabetes and glucose progression over time, independently of known risk factors for diabetes development. However, since MR-ANP levels might be influenced by unknown factors causing diabetes, we cannot rule out that such relationship might be confounded. Previous studies have shown an association of a single nucleotide polymorphism rs5068 on the natriuretic peptide precursor A (NPPA) locus gene with higher levels of circulating ANP. Since gene variants are inherited randomly and not subject to confounding, we aimed to investigate whether the variant rs5068 within the NPPA locus is associated with incident type 2 diabetes. We genotyped the variant rs5068 within the NPPA locus in 27,307 individuals without known diabetes from the Malmö Diet Cancer Study. Incident diabetes was retrieved through national and regional registers (median follow-up time of 14 years, 2,823 incident diabetes cases). In Cox regression analysis adjusted for age, sex and BMI, we found that the carriers of at least one copy of the G allele of rs5068 had lower likelihood of incident diabetes within 14 years (HR = 0.88, 95% CI 0.78–0.99, p = 0.037). Our results indicate a role of the ANP system in the etiology of type 2 diabetes and might help provide insight in the metabolic actions of natriuretic peptides and the pathophysiology of type 2 diabetes.
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影响因子：
16.2
作者：
Cannone V;Cefalu' AB;Noto D;Scott CG;Bailey KR;Cavera G;Pagano M;Sapienza M;Averna MR;Burnett JC Jr
通讯作者：
Burnett JC Jr
影响因子：
7.7
作者：
Janke, J;Engeli, S;Sharma, AM
通讯作者：
Sharma, AM
影响因子：
--
作者：
Jujic, Amra;Leosdottir, Margret;Magnusson, Martin
通讯作者：
Magnusson, Martin
影响因子：
8.3
作者：
Li, CR;Engström, G;Janzon, L
通讯作者：
Janzon, L
影响因子：
30.8
作者：
Newton-Cheh, Christopher;Johnson, Toby;Gateva, Vesela;Tobin, Martin D.;Bochud, Murielle;Coin, Lachlan;Najjar, Samer S.;Zhao, Jing Hua;Heath, Simon C.;Eyheramendy, Susana;Papadakis, Konstantinos;Voight, Benjamin F.;Scott, Laura J.;Zhang, Feng;Farrall, Martin;Tanaka, Toshiko;Wallace, Chris;Chambers, John C.;Khaw, Kay-Tee;Nilsson, Peter;van der Harst, Pim;Polidoro, Silvia;Grobbee, Diederick E.;Onland-Moret, N. Charlotte;Bots, Michiel L.;Wain, Louise V.;Elliott, Katherine S.;Teumer, Alexander;Luan, Jian'an;Lucas, Gavin;Kuusisto, Johanna;Burton, Paul R.;Hadley, David;McArdle, Wendy L.;Brown, Morris;Dominiczak, Anna;Newhouse, Stephen J.;Samani, Nilesh J.;Webster, John;Zeggini, Eleftheria;Beckmann, Jacques S.;Bergmann, Sven;Lim, Noha;Song, Kijoung;Vollenweider, Peter;Waeber, Gerard;Waterworth, Dawn M.;Yuan, Xin;Groop, Leif;Orho-Melander, Marju;Allione, Alessandra;Di Gregorio, Alessandra;Guarrera, Simonetta;Panico, Salvatore;Ricceri, Fulvio;Romanazzi, Valeria;Sacerdote, Carlotta;Vineis, Paolo;Barroso, Ines;Sandhu, Manjinder S.;Luben, Robert N.;Crawford, Gabriel J.;Jousilahti, Pekka;Perola, Markus;Boehnke, Michael;Bonnycastle, Lori L.;Collins, Francis S.;Jackson, Anne U.;Mohlke, Karen L.;Stringham, Heather M.;Valle, Timo T.;Willer, Cristen J.;Bergman, Richard N.;Morken, Mario A.;Doering, Angela;Gieger, Christian;Illig, Thomas;Meitinger, Thomas;Org, Elin;Pfeufer, Arne;Wichmann, H. Erich;Kathiresan, Sekar;Marrugat, Jaume;O'Donnell, Christopher J.;Schwartz, Stephen M.;Siscovick, David S.;Subirana, Isaac;Freimer, Nelson B.;Hartikainen, Anna-Liisa;McCarthy, Mark I.;O'Reilly, Paul F.;Peltonen, Leena;Pouta, Anneli;de Jong, Paul E.;Snieder, Harold;van Gilst, Wiek H.;Clarke, Robert;Goel, Anuj;Hamsten, Anders;Peden, John F.;Seedorf, Udo;Syvanen, Ann-Christine;Tognoni, Giovanni;Lakatta, Edward G.;Sanna, Serena;Scheet, Paul;Schlessinger, David;Scuteri, Angelo;Doerr, Marcus;Ernst, Florian;Felix, Stephan B.;Homuth, Georg;Lorbeer, Roberto;Reffelmann, Thorsten;Rettig, Rainer;Voelker, Uwe;Galan, Pilar;Gut, Ivo G.;Hercberg, Serge;Lathrop, G. Mark;Zelenika, Diana;Deloukas, Panos;Soranzo, Nicole;Williams, Frances M.;Zhai, Guangju;Salomaa, Veikko;Laakso, Markku;Elosua, Roberto;Forouhi, Nita G.;Volzke, Henry;Uiterwaal, Cuno S.;van der Schouw, Yvonne T.;Numans, Mattijs E.;Matullo, Giuseppe;Navis, Gerjan;Berglund, Goran;Bingham, Sheila A.;Kooner, Jaspal S.;Connell, John M.;Bandinelli, Stefania;Ferrucci, Luigi;Watkins, Hugh;Spector, Tim D.;Tuomilehto, Jaakko;Altshuler, David;Strachan, David P.;Laan, Maris;Meneton, Pierre;Wareham, Nicholas J.;Uda, Manuela;Jarvelin, Marjo-Riitta;Mooser, Vincent;Melander, Olle;Loos, Ruth J. F.;Elliott, Paul;Abecasis, Goncalo R.;Caulfield, Mark;Munroe, Patricia B.
通讯作者：
Munroe, Patricia B.