Polymers for drug delivery systems.
Polymers for drug delivery systems.
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DOI：
10.1146/annurev-chembioeng-073009-100847
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发表时间：
2010
影响因子：
8.4
通讯作者：
Peppas NA
中科院分区：
文献类型：
--
作者：
Liechty WB;Kryscio DR;Slaughter BV;Peppas NA
聚合物在药物递送技术的进步中发挥了不可或缺的作用，其通过提供治疗剂在长时间内以恒定剂量的受控释放、循环剂量以及亲水性和疏水性药物的可调释放。从使用现成材料的早期开始，该领域已经取得了巨大的发展，部分原因是化学工程师的创新。药物递送的现代进展现在基于为特定货物量身定制的聚合物的合理设计，并被工程化以发挥独特的生物功能。在这篇综述中，我们强调了基本的药物输送系统及其数学基础，并讨论了药物输送的生理障碍。本文综述了刺激响应性高分子系统和高分子治疗剂如高分子-蛋白质偶联物和高分子-药物偶联物的起源和应用。能够分子识别或指导细胞内交付的聚合物的最新发展进行了调查，以说明研究领域推进药物输送的前沿。
Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs. From early beginnings using off-the-shelf materials, the field has grown tremendously, driven in part by the innovations of chemical engineers. Modern advances in drug delivery are now predicated upon the rational design of polymers tailored for specific cargo and engineered to exert distinct biological functions. In this review, we highlight the fundamental drug delivery systems and their mathematical foundations and discuss the physiological barriers to drug delivery. We review the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates. The latest developments in polymers capable of molecular recognition or directing intracellular delivery are surveyed to illustrate areas of research advancing the frontiers of drug delivery.
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影响因子：
6.2
作者：
Chen, Rongjun;Khormaee, Sariah;Slater, Nigel K. H.
通讯作者：
Slater, Nigel K. H.
影响因子：
11.2
作者：
Chesler, Louis;Goldenberg, David D.;Weiss, William A.
通讯作者：
Weiss, William A.
DOI：
10.1016/s1461-5347(00)00269-8
发表时间：
2000-06-01
期刊：
Pharmaceutical science & technology today
影响因子：
--
作者：
Colombo;Bettini;Peppas
通讯作者：
Peppas
影响因子：
4.7
作者：
Bae, Younsoo;Nishiyama, Nobuhiro;Kataoka, Kazunori
通讯作者：
Kataoka, Kazunori
影响因子：
5.5
作者：
ALEXANDRIDIS, P;HOLZWARTH, JF;HATTON, TA
通讯作者：
HATTON, TA