Individual oligodendrocytes have only a few hours in which to generate new myelin sheaths in vivo.
Individual oligodendrocytes have only a few hours in which to generate new myelin sheaths in vivo.
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DOI：
10.1016/j.devcel.2013.05.013
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发表时间：
2013-06-24
影响因子：
11.8
通讯作者：
Lyons, David A.
中科院分区：
文献类型：
--
作者：
Czopka, Tim;Ffrench-Constant, Charles;Lyons, David A.
单个少突胶质细胞形成的髓鞘数量调节髓鞘形成的程度，这深刻影响中枢神经系统功能。目前尚不清楚单个少突胶质细胞在其一生中何时可以调节体内髓鞘数量。我们使用斑马鱼的实时成像表明，少突胶质细胞在短短 5 小时内形成新的髓鞘，此后髓鞘数量的调节仅限于偶尔的回缩。我们还表明，少突胶质细胞中 Fyn 激酶的激活和减少分别会增加和减少每个细胞的鞘数。有趣的是，这些少突胶质细胞也在同一时期产生新的髓鞘，尽管髓鞘形成的程度差异很大。我们的数据表明，相对于单个少突胶质细胞的寿命，有一个有限的时间窗口，在此期间发生髓鞘形成并确定髓鞘的数量。
The number of myelin sheaths made by individual oligodendrocytes regulates the extent of myelination, which profoundly affects central nervous system function. It remains unknown when, during their life, individual oligodendrocytes can regulate myelin sheath number in vivo. We show, using live imaging in zebrafish, that oligodendrocytes make new myelin sheaths during a period of just 5 hr, with regulation of sheath number after this time limited to occasional retractions. We also show that activation and reduction of Fyn kinase in oligodendrocytes increases and decreases sheath number per cell, respectively. Interestingly, these oligodendrocytes also generate their new myelin sheaths within the same period, despite having vastly different extents of myelination. Our data demonstrate a restricted time window relative to the lifetime of the individual oligodendrocyte, during which myelin sheath formation occurs and the number of sheaths is determined.
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影响因子：
16.2
作者：
Kang, Shin H.;Fukaya, Masahiro;Yang, Jason K.;Rothstein, Jeffrey D.;Bergles, Dwight E.
通讯作者：
Bergles, Dwight E.
影响因子：
16.2
作者：
Brinkmann, Bastian G.;Agarwal, Amit;Sereda, Michael W.;Garratt, Alistair N.;Mueller, Thomas;Wende, Hagen;Stassart, Ruth M.;Nawaz, Schanila;Humml, Christian;Velanac, Viktorija;Radyushkin, Konstantin;Goebbels, Sandra;Fischer, Tobias M.;Franklin, Robin J.;Lai, Cary;Ehrenreich, Hannelore;Birchmeier, Carmen;Schwab, Markus H.;Nave, Klaus Armin
通讯作者：
Nave, Klaus Armin
DOI：
10.1073/pnas.1117943109
发表时间：
2012-10-09
影响因子：
11.1
作者：
Miller, Daniel J.;Duka, Tetyana;Sherwood, Chet C.
通讯作者：
Sherwood, Chet C.
影响因子：
64.8
作者：
Fuenfschilling, Ursula;Supplie, Lotti M.;Mahad, Don;Boretius, Susann;Saab, Aiman S.;Edgar, Julia;Brinkmann, Bastian G.;Kassmann, Celia M.;Tzvetanova, Iva D.;Moebius, Wiebke;Diaz, Francisca;Meijer, Dies;Suter, Ueli;Hamprecht, Bernd;Sereda, Michael W.;Moraes, Carlos T.;Frahm, Jens;Goebbels, Sandra;Nave, Klaus-Armin
通讯作者：
Nave, Klaus-Armin
影响因子：
2.7
作者：
Ng, ANY;de Jong-Curtain, TA;Heath, JK
通讯作者：
Heath, JK