Laboratory characteristics analysis of the efficacy of levothyroxine on subclinical hypothyroidism during pregnancy: a single-center retrospective study.
Laboratory characteristics analysis of the efficacy of levothyroxine on subclinical hypothyroidism during pregnancy: a single-center retrospective study.
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左旋甲状腺素治疗妊娠期亚临床甲状腺功能减退症疗效的实验室特征分析：单中心回顾性研究
DOI：
10.1080/21655979.2021.1955589
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发表时间：
2021-12
期刊：
影响因子：
4.9
通讯作者：
Chen D
中科院分区：
文献类型：
--
作者：
Han L;Ma Y;Liang Z;Chen D
To reassess the efficacy of levothyroxine on subclinical hypothyroidism (SCH, 4.0 mIU/L ≤ TSH (thyroid stimulating hormone) <10 mIU/L with normal free T4) during pregnancy. 165 levothyroxine-treated pregnant women experiencing SCH were screened. And controls were randomly selected using euthyroidism (EU) women, matched by age, gravidity, and parity in the EU group (n = 660). We evaluated laboratory characteristics and pregnancy outcomes during follow-ups. Compared with the EU group, the SCH group displayed higher inadequate maternal gestational weight gain, premature delivery, low birth weight offspring and infant offspring small for their gestational age. After levothyroxine treatment, the SCH group displayed lower total cholesterol, low-density lipoprotein levels, and higher serum homocysteine levels before delivery. Pregnant women with SCH still exhibit adverse pregnancy outcomes after levothyroxine treatment. Taken together, we believe that besides levothyroxine, vitamin B12 and folic acid could be added to the treatment of pregnant women with SCH. In addition, regular monitoring of blood sugar levels, lipid and homocysteine levels, and intervention gestational weight gain could alleviate the adverse effects of SCH on pregnancy outcomes.
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影响因子：
2.8
作者：
El Rafei, Rym;Abbas, Hussein A.;Yunis, Khalid A.
通讯作者：
Yunis, Khalid A.
甲状腺功能减退症患者的同型半胱氨酸与低密度脂蛋白胆固醇之间的潜在有害相关性。
影响因子：
1.6
作者：
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通讯作者：
Wang G
影响因子：
6.6
作者：
Alexander, Erik K.;Pearce, Elizabeth N.;Sullivan, Scott
通讯作者：
Sullivan, Scott
影响因子：
5.8
作者：
De Groot, Leslie;Abalovich, Marcos;Sullivan, Scott
通讯作者：
Sullivan, Scott
影响因子：
2
作者：
Ceyhan, Seyit T.;Beyan, Cengiz;Baser, Iskender
通讯作者：
Baser, Iskender