Hemispheric lateralization of a molecular signal for pain modulation in the amygdala.
Hemispheric lateralization of a molecular signal for pain modulation in the amygdala.
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DOI：
10.1186/1744-8069-4-24
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发表时间：
2008-06-23
期刊：
影响因子：
3.3
通讯作者：
Gereau RW 4th
中科院分区：
文献类型：
--
作者：
Carrasquillo Y;Gereau RW 4th
细胞外信号调节激酶（ERK）级联反应是小鼠杏仁核中央核（CeA）疼痛过程的关键调节因子。ERK在持续性炎性疼痛期间在CeA中被激活，并且这种激活对于诱导外周触觉超敏性是必要的且足够的。有趣的是，生物化学研究表明，炎症诱导的ERK激活CeA只发生在右半球，而不是左半球。这种炎症诱导的ERK激活在右侧CeA是独立的外周炎症的一面，这表明有一个主导作用的调制疼痛的右侧大脑半球的ERK激活CeA。然而，这种生物化学偏侧化的功能意义尚未确定。在本研究中，我们测试了这一假设，即调制疼痛的ERK信号在CeA的功能偏侧。我们通过将MEK抑制剂U0126注入到右半球或左半球来急性阻断CeA中的ERK激活，然后测量对小鼠炎症诱导的机械超敏性的行为影响。我们的研究结果表明，阻断ERK激活的权利，而不是左CeA，降低炎症诱导的外周超敏反应的外周损伤的一面无关。这些研究结果表明，ERK信号在CeA的疼痛调制功能偏侧的右半球，这表明在疼痛处理的右杏仁核的主导作用。
The extracellular signal-regulated kinase (ERK) cascade has been shown to be a key modulator of pain processing in the central nucleus of the amygdala (CeA) in mice. ERK is activated in the CeA during persistent inflammatory pain and this activation is both necessary and sufficient to induce peripheral tactile hypersensitivity. Interestingly, biochemical studies show that inflammation-induced ERK activation in the CeA only occurs in the right, but not the left hemisphere. This inflammation-induced ERK activation in the right CeA is independent of the side of peripheral inflammation, suggesting that there is a dominant role of the right hemisphere in the modulation of pain by ERK activation in the CeA. However, the functional significance of this biochemical lateralization has yet to be determined. In the present study, we tested the hypothesis that modulation of pain by ERK signaling in the CeA is functionally lateralized. We acutely blocked ERK activation in the CeA by infusing the MEK inhibitor U0126 into the right or the left hemisphere and then measured the behavioral effects on inflammation-induced mechanical hypersensitivity in mice. Our results show that blockade of ERK activation in the right, but not the left CeA, decreases inflammation-induced peripheral hypersensitivity independent of the side of peripheral injury. These findings demonstrate that modulation of pain by ERK signaling in the CeA is functionally lateralized to the right hemisphere, suggesting a dominant role of the right amygdala in pain processing.
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影响因子：
8.2
作者：
Adamec, RE;Blundell, J;Collins, A
通讯作者：
Collins, A
DOI：
10.1016/j.pnpbp.2003.09.017
发表时间：
2003-12-01
影响因子：
5.6
作者：
Adamec, RE;Blundell, J;Burton, P
通讯作者：
Burton, P
影响因子：
5.3
作者：
Carrasquillo, Yarimar;Gereau, Robert W.
通讯作者：
Gereau, Robert W.
影响因子：
3.5
作者：
Lu, CL;Wu, YT;Hsieh, JC
通讯作者：
Hsieh, JC
DOI：
10.1097/00146965-200403000-00002
发表时间：
2004-03-01
期刊：
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
影响因子：
--
作者：
Lee, Gregory P;Meador, Kimford J;Lavin, Thomas B
通讯作者：
Lavin, Thomas B