Clinical characteristics of Kawasaki disease and concurrent pathogens during isolation in COVID-19 pandemic.
Clinical characteristics of Kawasaki disease and concurrent pathogens during isolation in COVID-19 pandemic.
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COVID-19大流行期间隔离期间川崎病和并发病原体的临床特征
DOI：
10.1007/s12519-021-00431-2
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Lv HT
中科院分区：
文献类型：
--
作者：
Ding YY;Ren Y;Qin J;Qian GH;Tang YJ;Chen Y;Li X;Xu L;Qiao CH;Sun L;Lv HT
本研究旨在探讨2019年新冠肺炎流行期间，川崎病(KD)及因采取居家隔离政策而并发病原体的特点。将2015-2020年2-4月收治的KD患者分为隔离前(组1,2015-2019年)和隔离后(组2,2020)两组。对2020年确诊为肺炎支原体(MP)和病毒检测的4 742例KD(n = 98例)和非KD(n = 4644例)患者进行了分析。对其临床特点、实验室资料及13种病原菌进行回顾性分析。组2的KD发生率(0.11%)显著高于组1(0.03%)(493例)。口腔粘膜改变、草莓舌、指尖脱屑、颈淋巴结病和中性粒细胞百分率比较，2组明显低于1组，MP感染率(34.7%)明显高于1组(19.3%)，病毒阳性率(5.3%)明显低于1组(14.3%)。2020年，KD患者MP感染阳性率明显高于非KD患者。2组3岁以下儿童MP感染率高于1组。与2015-2019年KD发病特点相比，2020年KD发病率呈上升趋势，并伴随着MP感染的高发，尤其是在新冠肺炎大流行隔离期间，尤其是3岁以下儿童。
The aim of this study is to explore the characteristics of Kawasaki disease (KD) and concurrent pathogens due to a stay-at-home isolation policy during coronavirus disease 2019 (COVID-19) epidemic. All patients with KD admitted between February and April in 2015–2020, were classified into before (group 1, in 2015–2019) and after (group 2, in 2020) isolation groups. A total of 4742 patients [with KD (n = 98) and non-KD (n = 4644)] referred to Mycoplasma pneumoniae (MP) and virus detection were analyzed in 2020. Clinical characteristics, laboratory data, and 13 pathogens were analyzed retrospectively. Group 2 had a significantly increased incidence of KD (0.11%) with 107 patients compared to that of group 1 (0.03%) with 493 patients. The comparisons of oral mucosal change, strawberry tongue, desquamation of the fingertips, cervical lymphadenopathy and neutrophil percentage decreased in group 2 compared to group 1. The infection rate of MP increased significantly in group 2 (34.7%) compared to group 1 (19.3%), while the positive rate of viruses decreased significantly in group 2 (5.3%) compared to group 1 (14.3%). In 2020, the positive rate of MP infection increased significantly in patients with KD compared to the increase in patients with non-KD. The infection rate of MP for younger children aged less than 3 years old was higher in group 2 than in group 1. Compared with the characteristics of KD from 2015 to 2019 years, the incidence of KD was increased in 2020 and was accompanied by a high incidence of MP infection, especially in younger children (less than 3 years old) during the isolation due to COVID-19 pandemic.
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1.6
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