Effects of Glucose on Scopolamine-Induced Learning Deficits in Rats Performing the Morris Water Maze Task
Effects of Glucose on Scopolamine-Induced Learning Deficits in Rats Performing the Morris Water Maze Task
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葡萄糖对东莨菪碱引起的执行莫里斯水迷宫任务的大鼠学习缺陷的影响
DOI：
10.1006/nlme.1999.3940
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发表时间：
2000
影响因子：
2.7
通讯作者：
H. Okaichi
中科院分区：
文献类型：
--
作者：
Y. Okaichi;H. Okaichi
In order to assess the effects of glucose on drug-induced spatial learning deficits, three experiments were conducted using the Morris water maze. Scopolamine and glucose were injected ip at various stages of training. Rats of Wistar strain served as subjects. In Experiment 1, scopolamine (0.4 mg/kg) and 10, 100, or 500 mg/kg of glucose were administered every day from the start of training, and the effect on acquisition was evaluated. In Experiment 2, scopolamine and 100 or 500 mg/kg of glucose were administered after 6 days of training, and the effect on performance was assessed. In Experiment 3, scopolamine and 500 mg/kg of glucose were injected after 2 days of training, and the effect on the following trial was tested. In all experiments, scopolamine impaired acquisition/performance of the task. Glucose at 500 mg/kg showed a significant enhancing effect on acquisition regardless of scopolamine injection only when injected daily from the start of training (Experiment 1). Glucose injected after the performance has reached asymptote (Experiment 2) did not affect performance, and glucose in the middle of training showed a slight but insignificant enhancing effect (Experiment 3). These results may suggest that the effect of glucose changes as a function of the degree of learning of the spatial learning task. The possibility of task specificity of the glucose effect was also discussed in relation to the cholinergic systems and local cerebral glucose utilization.
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DOI：
10.1073/pnas.93.10.4693
发表时间：
1996-05
影响因子：
11.1
作者：
M. Ragozzino;Katharine E. Unick;Katharine E. Unick;Paul E. Gold
通讯作者：
M. Ragozzino;Katharine E. Unick;Katharine E. Unick;Paul E. Gold
影响因子：
1.9
作者：
W. Stone;B. Walser;Sigfried Gold;P. E. Gold
通讯作者：
W. Stone;B. Walser;Sigfried Gold;P. E. Gold
胆碱可增强清醒、自由活动大鼠背侧海马中东莨菪碱诱导的乙酰胆碱释放。
影响因子：
6.1
作者：
Jackson,DA;Kischka,U;Wurtman,RJ
通讯作者：
Wurtman,RJ
高血糖对阿尔茨海默型痴呆患者记忆和激素水平的影响：一项纵向研究。
影响因子：
1.9
作者：
Craft,S;Dagogo-Jack,SE;Wiethop,BV;Murphy,C;Nevins,RT;Fleischman,S;Rice,V;Newcomer,JW;Cryer,PE
通讯作者：
Cryer,PE
DOI：
10.1016/s0163-1047(86)80022-x
发表时间：
1986-05-01
期刊：
BEHAVIORAL AND NEURAL BIOLOGY
影响因子：
--
作者：
GOLD, PE
通讯作者：
GOLD, PE