Pharmaceutically relevant (hetero)cyclic compounds and natural products from lignin-derived monomers: Present and perspectives.
Pharmaceutically relevant (hetero)cyclic compounds and natural products from lignin-derived monomers: Present and perspectives.
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DOI：
10.1016/j.isci.2021.102211
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发表时间：
2021-03-19
期刊：
影响因子：
5.8
通讯作者：
Barta K
中科院分区：
文献类型：
--
作者：
Afanasenko A;Barta K
木质素是地球上最丰富的可再生芳烃来源，是构建增值芳烃的有趣原材料。在过去的十年中，在开发有效的木质素解聚方法方面取得了很大进展，能够以足够高的选择性和产率生产特定的单酚衍生物。现在，这为开发针对各种产品（包括精细化工构件）的强大下游转化策略奠定了良好的基础。木质素衍生平台化学品的固有结构特征无疑激发了针对生物活性分子或天然产物的新型、创造性、原子经济合成路线的开发。从这个角度来看，我们试图将木质素衍生平台化学品的结构特征与构建杂环的现有合成策略联系起来，并总结从原则上可以从木质素中获得的芳烃生产天然产物的努力。最后，我们评论了呈现从木材到有价值的医药相关化合物的整个价值链的最新努力。化学;有机化学；绿色化学；过程生物技术
Lignin, the richest source of renewable aromatics on the planet, is an intriguing raw material for the construction of value-added aromatics. In the past decade, much progress has been made regarding the development of efficient lignin depolymerization methods, able to produce specific monophenol derivatives in high-enough selectivity and yields. This now serves as an excellent basis for developing powerful downstream conversion strategies toward a wide range of products, including fine chemical building blocks. The inherent structural features of lignin-derived platform chemicals undoubtedly inspire the development of novel, creative, atom-economic synthetic routes toward biologically active molecules or natural products. In this perspective we attempt to bridge the structural features of lignin-derived platform chemicals with existing synthetic strategies toward the construction of heterocycles and provide a summary of efforts for the production of natural products from aromatics that can be, in principle, obtained from lignin. Last, we comment on the latest efforts that present entire value-chains from wood to valuable pharmaceutically relevant compounds. Chemistry; Organic Chemistry; Green Chemistry; Process Biotechnology
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