In vivo impedance spectroscopy of deep brain stimulation electrodes.
In vivo impedance spectroscopy of deep brain stimulation electrodes.
复制标题
DOI：
10.1088/1741-2560/6/4/046001
复制
发表时间：
2009-08
影响因子：
4
通讯作者：
McIntyre CC
中科院分区：
文献类型：
--
作者：
Lempka SF;Miocinovic S;Johnson MD;Vitek JL;McIntyre CC
脑深部刺激(DBS)是一种强大的临床技术，但缺乏对电极和大脑之间电相互作用的系统表征。这项研究的目的是检查植入后和临床相关刺激过程中DBS电极阻抗的体内变化。临床DBS设备通常采用高频电压控制刺激，因此注入电流直接由电极-组织界面的阻抗调节。我们使用从0.5赫兹到10千赫的电极阻抗谱(EIS)测量了植入恒河猴丘脑和丘脑底核的临床DBS电极的阻抗。为了进一步表征我们的测量结果，我们使用了电极-组织界面的等效电路模型来量化各种界面成分在产生观察到的电极阻抗中的作用。植入后，DBS电极阻抗增加，并在EIS测量的高频范围内观察到半圆弧，通常称为阻抗的组织成分。与临床相关的刺激导致电极阻抗迅速降低，组织成分发生广泛变化。这些术后和刺激引起的阻抗变化可能在观察到的电压控制DBS的功能效应中发挥重要作用，在临床刺激参数选择和慢性动物研究中应予以考虑。
Deep brain stimulation (DBS) represents a powerful clinical technology, but a systematic characterization of the electrical interactions between the electrode and the brain are lacking. The goal of this study was to examine the in vivo changes in DBS electrode impedance that occur after implantation and during clinically-relevant stimulation. Clinical DBS devices typically apply high-frequency voltage-controlled stimulation, and as a result the injected current is directly regulated by the impedance of the electrode-tissue interface. We monitored the impedance of scaled-down clinical DBS electrodes implanted in the thalamus and subthalamic nucleus of a rhesus macaque using electrode impedance spectroscopy (EIS) measurements ranging from 0.5 Hz to 10 kHz. To further characterize our measurements, equivalent circuit models of the electrode-tissue interface were used to quantify the role of various interface components in producing the observed electrode impedance. Following implantation, DBS electrode impedance increased and a semicircular arc was observed in the high frequency range of the EIS measurements, commonly referred to as the tissue component of the impedance. Clinically-relevant stimulation produced a rapid decrease in electrode impedance with extensive changes in the tissue component. These post-operative and stimulation-induced changes in impedance could play an important role in the observed functional effects of voltage-controlled DBS and should be considered during clinical stimulation parameter selection and chronic animal research studies.
登录
查看更多内容
影响因子：
3.8
作者：
MACDONALD, JR
通讯作者：
MACDONALD, JR
影响因子：
2.8
作者：
Hemm, S;Vayssiere, N;Coubes, P
通讯作者：
Coubes, P
影响因子：
5.1
作者：
Nielsen, M. S.;Bjarkam, C. R.;Ostergaard, K.
通讯作者：
Ostergaard, K.
影响因子：
4.7
作者：
Butson, CR;Maks, CB;McIntyre, CC
通讯作者：
McIntyre, CC
影响因子：
5.3
作者：
Miocinovic, Svjetlana;Lempka, Scott F.;Russo, Gary S.;Maks, Christopher B.;Butson, Christopher R.;Sakaie, Ken E.;Vitek, Jerrold L.;McIntyre, Cameron C.
通讯作者：
McIntyre, Cameron C.