The function of BMP4 during neurogenesis in the adult hippocampus in Alzheimer's disease
The function of BMP4 during neurogenesis in the adult hippocampus in Alzheimer's disease
复制标题
BMP4在阿尔茨海默病成人海马神经发生过程中的功能
DOI：
10.1016/j.arr.2012.05.002
复制
发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
YIn ZQ
中科院分区：
文献类型：
--
作者：
Xu H,;Fan X;Huang W,;Wang Y,;Sun W,;Tang J;Li D;Xu P;Guo L;YIn ZQ
阿尔茨海默病(AD)是一种与年龄相关的、进行性和不可逆转的神经退行性疾病，其结果是基底前脑、杏仁核、海马区和皮质区的选定神经元丢失，以及进行性认知和记忆障碍。海马齿状回颗粒下区(SGZ)是哺乳动物成体神经发生的区域之一，包括人类和非人类灵长类动物。新生的颗粒细胞是DG中主要的兴奋性神经元，参与学习和记忆过程。阿尔茨海默病发病初期和进展过程中神经发生的变化表明，神经源性部位新产生的神经元的调节可能对海马区的功能产生深远的影响。骨形态发生蛋白-4(BMP4)及其拮抗剂Noggin参与了成年海马区神经发生的调节，从而影响海马区的功能。本文综述了BMP4和Noggin在AD期间对成年海马区干细胞和前体细胞的调控作用，以及它们作为AD患者可能的治疗策略的可能性。这有助于扩大对正常和病变海马区干细胞控制的理解。
Alzheimer's disease (AD) is an age-related, progressive and irreversible neurodegenerative disease that results in the loss of selected neurons throughout the basal forebrain, amygdala, hippocampus, and cortical area as well as progressive deficits of cognition and memory. The subgranular zone (SGZ) of the hippocampal dentate gyrus (DG) is one of the regions where adult neurogenesis occurs in mammals, including humans and non-human primates. The new granule cells, which are the primary excitatory neurons in the DG, contribute to the processes of learning and memory. The changes in neurogenesis observed during the initial stages and progression of AD suggest that the modulation of the new production of neurons at neurogenic sites may exert profound effects on hippocampal function. Bone morphogenetic protein-4 (BMP4) and its antagonist Noggin contribute to the modulation of neurogenesis in the adult hippocampus, thereby affecting hippocampal function. This review focuses on the role of BMP4 and Noggin in the control of the stem and precursor cells in the adult hippocampus during AD and their potential as a possible therapeutic strategy for AD sufferers. It is helpful to extend the understanding of the control of stem cells in the normal and diseased hippocampus.
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DOI：
10.1523/jneurosci.22-22-09785.2002
发表时间：
2002-11
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
Orly Lazarov;Michael K. Lee;D. Peterson;S. Sisodia
通讯作者：
Orly Lazarov;Michael K. Lee;D. Peterson;S. Sisodia
影响因子：
5.9
作者：
Babcock KR;Page JS;Fallon JR;Webb AE
通讯作者：
Webb AE
影响因子：
64.5
作者：
Bonaguidi MA;Wheeler MA;Shapiro JS;Stadel RP;Sun GJ;Ming GL;Song H
通讯作者：
Song H
影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
影响因子：
6.2
作者：
C. López-García
通讯作者：
C. López-García