Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury.
Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury.
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不同的少突胶质细胞群体对脊髓损伤有不同的空间偏好和反应。
DOI：
10.1038/s41467-020-19453-x
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发表时间：
2020-11-17
影响因子：
16.6
通讯作者：
Castelo-Branco G
中科院分区：
文献类型：
--
作者：
Floriddia EM;Lourenço T;Zhang S;van Bruggen D;Hilscher MM;Kukanja P;Gonçalves Dos Santos JP;Altınkök M;Yokota C;Llorens-Bobadilla E;Mulinyawe SB;Grãos M;Sun LO;Frisén J;Nilsson M;Castelo-Branco G
成熟少突胶质细胞（MOLs）表现出转录异质性，其功能后果尚不清楚。MOL的异质性可能与局部环境或它们与不同神经元类型的相互作用有关。在这里，我们发现不同的MOL种群在哺乳动物中枢神经系统（CNS）中具有空间偏好。我们发现，与大脑相比，MOL2型（MOL2）在脊髓中丰富，而MOL5型和MOL 6型（MOL5/6）在所有分析区域中随着年龄的增长而增加。MOL2和MOL5/6在运动束和感觉束运行的脊髓区域也有明显的空间偏好。在发育过程中，OL祖细胞（OPC）没有被指定为不同的MOL群体，排除了OPC决定MOL异质性的内在机制的主要贡献。在疾病中，在创伤性脊髓损伤后的慢性期，MOL2和MOL5/6表现出不同的易感性。结果表明，不同的MOL种群具有不同的空间偏好和不同的疾病反应。少突胶质细胞谱系以其转录异质性而闻名，但其功能后果尚不清楚。在这里，作者表明，不同的成熟少突胶质细胞群体在脑和脊髓中具有空间偏好，并对脊髓损伤表现出不同的反应。
Mature oligodendrocytes (MOLs) show transcriptional heterogeneity, the functional consequences of which are unclear. MOL heterogeneity might correlate with the local environment or their interactions with different neuron types. Here, we show that distinct MOL populations have spatial preference in the mammalian central nervous system (CNS). We found that MOL type 2 (MOL2) is enriched in the spinal cord when compared to the brain, while MOL types 5 and 6 (MOL5/6) increase their contribution to the OL lineage with age in all analyzed regions. MOL2 and MOL5/6 also have distinct spatial preference in the spinal cord regions where motor and sensory tracts run. OL progenitor cells (OPCs) are not specified into distinct MOL populations during development, excluding a major contribution of OPC intrinsic mechanisms determining MOL heterogeneity. In disease, MOL2 and MOL5/6 present different susceptibility during the chronic phase following traumatic spinal cord injury. Our results demonstrate that the distinct MOL populations have different spatial preference and different responses to disease. The oligodendrocyte lineage is known for its transcriptional heterogeneity, but the functional consequences of this are unclear. Here, the authors show that distinct populations of mature oligodendrocytes have spatial preferences in the brain and spinal cord and show different responses to spinal cord injury.
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影响因子：
25
作者：
Hughes EG;Orthmann-Murphy JL;Langseth AJ;Bergles DE
通讯作者：
Bergles DE
影响因子：
46.9
作者：
Becht, Etienne;McInnes, Leland;Newell, Evan W.
通讯作者：
Newell, Evan W.
影响因子：
16.2
作者：
Kang, Shin H.;Fukaya, Masahiro;Yang, Jason K.;Rothstein, Jeffrey D.;Bergles, Dwight E.
通讯作者：
Bergles, Dwight E.
影响因子：
2.5
作者：
FOX, MW;INMAN, OR;HIMWICH, WA
通讯作者：
HIMWICH, WA
影响因子：
15.9
作者：
Laranjeira, Catia;Sandgren, Katarina;Pachnis, Vassilis
通讯作者：
Pachnis, Vassilis