Fighting Fire With Fire: Oncolytic Virotherapy for Thoracic Malignancies.
Fighting Fire With Fire: Oncolytic Virotherapy for Thoracic Malignancies.
复制标题
DOI：
10.1245/s10434-020-09477-4
复制
发表时间：
2021-05
影响因子：
3.7
通讯作者：
Dhupar R
中科院分区：
文献类型：
--
作者：
Ekeke CN;Russell KL;Joubert K;Bartlett DL;Luketich JD;Soloff AC;Guo ZS;Lotze MT;Dhupar R
胸部恶性肿瘤与高死亡率相关。由于局部复发和远处转移的高发生率，许多胸部恶性肿瘤患者无法接受常规治疗。幸运的是，免疫疗法的发展为局部和全身治疗提供了有效的策略，在过去十年中迅速发展。一种有希望的癌症免疫治疗方法是使用溶瘤病毒，其具有相对高的肿瘤特异性、选择性复制介导的溶瘤、增强的抗原呈递和递送免疫原性有效载荷如细胞因子的潜力，随后引发有效的抗肿瘤免疫的优点。已经开发了几种溶瘤病毒，包括腺病毒、柯萨奇病毒B3、疱疹病毒、麻疹病毒、呼肠孤病毒和牛痘病毒，并在临床前小鼠研究和临床试验中应用于胸部癌症。这篇综述讨论了溶瘤病毒治疗肺癌，食管癌和转移性恶性胸腔积液的现状，并认为其作为这些患者的紧急治疗的潜力。
Thoracic malignancies are associated with high mortality rates. Conventional therapy for many of the patients with thoracic malignancies is obviated by a high incidence of locoregional recurrence and distant metastasis. Fortunately, developments in immunotherapy provide effective strategies for both local and systemic treatments that have rapidly advanced during the last decade. One promising approach to cancer immunotherapy is to use oncolytic viruses, which have the advantages of relatively high tumor specificity, selective replication-mediated oncolysis, enhanced antigen presentation, and potential for delivery of immunogenic payloads such as cytokines, with subsequent elicitation of effective antitumor immunity. Several oncolytic viruses including adenovirus, coxsackievirus B3, herpes virus, measles virus, reovirus, and vaccinia virus have been developed and applied to thoracic cancers in preclinical murine studies and clinical trials. This review discusses the current state of oncolytic virotherapy in lung cancer, esophageal cancer, and metastatic malignant pleural effusions and considers its potential as an emergent therapeutic for these patients.
登录
查看更多内容
影响因子：
5.1
作者：
Guan, Yong-song;Liu, Yuan;Hu, Ying
通讯作者：
Hu, Ying
影响因子：
6.7
作者：
Ahmad, Zeeshan;Kratzke, Robert A.
通讯作者：
Kratzke, Robert A.
在一项回顾性研究中，改良的 ECHO-7 病毒 Rigvir 免疫疗法（溶瘤病毒疗法）可延长黑色素瘤患者手术切除肿瘤后的生存期。
影响因子：
2.2
作者：
Doniņa S;Strēle I;Proboka G;Auziņš J;Alberts P;Jonsson B;Venskus D;Muceniece A
通讯作者：
Muceniece A
影响因子：
4.7
作者：
Dash AS;Patel MR
通讯作者：
Patel MR
影响因子：
9.6
作者：
Burrows, CM;Mathews, C;Colt, HG
通讯作者：
Colt, HG