Complementary encoding of spatial information in hippocampal astrocytes.
Complementary encoding of spatial information in hippocampal astrocytes.
复制标题
DOI：
10.1371/journal.pbio.3001530
复制
发表时间：
2022-03
期刊：
影响因子：
9.8
通讯作者：
Fellin T
中科院分区：
文献类型：
--
作者：
Curreli S;Bonato J;Romanzi S;Panzeri S;Fellin T
钙动态进入星形胶质细胞影响附近神经元结构的活动。然而，由于先前的报道表明星形细胞钙信号在很大程度上反映了邻近神经元的活动，目前的信息编码模型忽略了星形细胞。通过对小鼠在虚拟环境中导航的海马中的星形胶质细胞和神经元同时进行双光子钙成像，我们证明星形胶质细胞钙信号编码（即统计反映）了无法通过视觉线索信息解释的空间信息。携带空间信息的钙事件发生在地形组织的星形细胞亚区。重要的是，星形胶质细胞编码的空间信息与神经元携带的空间信息是互补和协同的，当星形胶质细胞信号与神经元信号一起考虑时，星形胶质细胞信号可以改善空间位置解码。这些结果表明，局部星形细胞钙信号的互补位置依赖性可能调节附近突触的簇，从而使脑回路中种群编码的动态，上下文依赖的变化成为可能。结合小鼠海马星形胶质细胞和神经元的功能成像和信息理论分析表明，星形胶质细胞的地形组织亚细胞区域中的钙动力学编码有关动物位置的信息，这些信息与周围神经元的spike输出编码的信息互补和协同。
Calcium dynamics into astrocytes influence the activity of nearby neuronal structures. However, because previous reports show that astrocytic calcium signals largely mirror neighboring neuronal activity, current information coding models neglect astrocytes. Using simultaneous two-photon calcium imaging of astrocytes and neurons in the hippocampus of mice navigating a virtual environment, we demonstrate that astrocytic calcium signals encode (i.e., statistically reflect) spatial information that could not be explained by visual cue information. Calcium events carrying spatial information occurred in topographically organized astrocytic subregions. Importantly, astrocytes encoded spatial information that was complementary and synergistic to that carried by neurons, improving spatial position decoding when astrocytic signals were considered alongside neuronal ones. These results suggest that the complementary place dependence of localized astrocytic calcium signals may regulate clusters of nearby synapses, enabling dynamic, context-dependent variations in population coding within brain circuits. A combination of functional imaging of astrocytes and neurons in the mouse hippocampus with information theory analysis shows that calcium dynamics in topographically-organized subcellular regions of astrocytes encode information about an animal’s position that is complementary and synergistic to that encoded in the spike output of surrounding neurons.
登录
查看更多内容
影响因子：
64.8
作者：
Attardo A;Fitzgerald JE;Schnitzer MJ
通讯作者：
Schnitzer MJ
影响因子：
25
作者：
Dombeck, Daniel A.;Harvey, Christopher D.;Tian, Lin;Looger, Loren L.;Tank, David W.
通讯作者：
Tank, David W.
影响因子：
56.9
作者：
Bindocci, Erika;Savtchouk, Iaroslav;Volterra, Andrea
通讯作者：
Volterra, Andrea
影响因子：
16.2
作者：
Agarwal A;Wu PH;Hughes EG;Fukaya M;Tischfield MA;Langseth AJ;Wirtz D;Bergles DE
通讯作者：
Bergles DE
影响因子：
7.7
作者：
Forli A;Pisoni M;Printz Y;Yizhar O;Fellin T
通讯作者：
Fellin T