SARS-CoV-2 Omicron Variant, Lineage BA.1, Is Associated with Lower Viral Load in Nasopharyngeal Samples Compared to Delta Variant.
SARS-CoV-2 Omicron Variant, Lineage BA.1, Is Associated with Lower Viral Load in Nasopharyngeal Samples Compared to Delta Variant.
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DOI：
10.3390/v14050919
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发表时间：
2022-04-28
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
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作者：
目的：Delta病例中观察到的上呼吸道标本中的高病毒载量可能导致其感染性高于其他变体。然而，还没有记录表明Omicron变异体增强的感染性是否也与更高的病毒载量有关。我们的目的是确定Omicron变体的传播是否也与Delta变体相比更高的病毒载量有关。研究方法：2021年12月期间，在法国里昂大学医院采集了来自医护人员的鼻咽拭子，129份（Omicron）和85份（Delta）。cobas® 6800 SARS-CoV-2检测试剂的RdRp靶标的循环阈值（Ct）用作评价SARS-CoV-2病毒载量的替代指标。使用筛选组进行变体鉴定，并通过全基因组测序确认。结果如下：在此，我们发现，在症状发作后5天内采样的医护人员中，Omicron病例的RT-PCR Ct值显著高于Delta病例（Delta变异体为21.7，Omicron变异体为23.8，p = 0.008）。在完全接种疫苗的患者中也观察到这种差异。结论：这一结果支持了表明Omicron的传播性增加与其他机制有关而不是更高的病毒排泄的研究。
Objectives: High viral load in upper respiratory tract specimens observed for Delta cases might contribute to its increased infectivity compared to the other variant. However, it is not yet documented if the Omicron variant’s enhanced infectivity is also related to a higher viral load. Our aim was to determine if the Omicron variant’s spread is also related to higher viral loads compared to the Delta variant. Methods: Nasopharyngeal swabs, 129 (Omicron) and 85 (Delta), from Health Care Workers were collected during December 2021 at the University Hospital of Lyon, France. Cycle threshold (Ct) for the RdRp target of cobas® 6800 SARS-CoV-2 assay was used as a proxy to evaluate SARS-CoV-2 viral load. Variant identification was performed using a screening panel and confirmed by whole genome sequencing. Results: Herein, we showed that the RT-PCR Ct values in Health Care Workers sampled within 5 days after symptom onset were significantly higher for Omicron cases than Delta cases (21.7 for Delta variant and 23.8 for Omicron variant, p = 0.008). This difference was also observed regarding patient with complete vaccination. Conclusions: This result supports the studies showing that the increased transmissibility of Omicron is related to other mechanisms than higher virus excretion.
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影响因子：
4.6
作者：
Tanaka S;Nelson G;Olson CA;Buzko O;Higashide W;Shin A;Gonzalez M;Taft J;Patel R;Buta S;Richardson A;Bogunovic D;Spilman P;Niazi K;Rabizadeh S;Soon-Shiong P
通讯作者：
Soon-Shiong P
DOI：
10.2807/1560-7917.es.2021.26.37.2100824
发表时间：
2021-09
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Blanquart F;Abad C;Ambroise J;Bernard M;Cosentino G;Giannoli JM;Débarre F
通讯作者：
Débarre F
影响因子：
6.4
作者：
Kidd, Michael;Richter, Alex;McNally, Alan
通讯作者：
McNally, Alan
影响因子：
64.8
作者：
Planas, Delphine;Veyer, David;Schwartz, Olivier
通讯作者：
Schwartz, Olivier
影响因子：
64.8
作者：
Volz, Erik;Mishra, Swapnil;Ferguson, Neil M.
通讯作者：
Ferguson, Neil M.