Thalamic dopaminergic neurons projects to the paraventricular nucleus-rostral ventrolateral medulla/C1 neural circuit.
Thalamic dopaminergic neurons projects to the paraventricular nucleus-rostral ventrolateral medulla/C1 neural circuit.
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DOI：
10.1002/ar.23528
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Francis J
中科院分区：
文献类型：
--
作者：
Ogundele OM;Lee CC;Francis J
室旁核（PVN）投射到延髓头端腹外侧区（RVLM）/C1儿茶酚胺能神经元群构成了参与全身心血管功能神经控制的前自主交感神经中枢。然而，下丘脑外和丘脑多巴胺能输入在这一电路中的作用仍有待探讨。利用逆行神经解剖追踪和高对比度共聚焦成像技术，我们研究了下丘脑背侧区（DHA）的离散丘脑多巴胺能神经元群的投射和形态及其对PVN-RVLM神经回路的贡献。我们发现，在RVLM/C1中注射逆行示踪剂后，在不确定带（Zi; 60%）和Reuniens丘脑核（Re; 40%）中的多巴胺（DA）能神经元亚群被标记为与PVN平行（85%）（p<0.01平均值±SEM）。Re/Zi DA神经元亚群的特征是细胞体成角，上内侧和下内侧投射分别到达对侧Re/Zi和同侧PVN DA神经元。最后，我们推断，多巴胺能投射的Re/Zi的PVN有助于PVN-RVLM/C1神经回路。作为这些连接的结果，Re/Zi多巴胺能神经元群可以调节与PVN-RVLM通路相关的自主神经前交感神经事件。
Paraventricular nuclei (PVN) projections to the rostral ventrolateral medulla (RVLM)/C1 catecholaminergic neuron group constitute the pre-autonomic sympathetic center involved in the neural control of systemic cardiovascular function. However, the role of extra-hypothalamic and thalamic dopaminergic inputs in this circuit remains underexplored. Using retrograde neuroanatomical tracing and high contrast confocal imaging methods, we investigated the projections and morphology of the discrete thalamic dopaminergic neuron groups in the dorsal hypothalamic area (DHA) and their contribution to the PVN-RVLM neural circuit. We found that dopaminergic (DA) neuron sub-groups in the Zona Incerta (Zi; 60%) and Reuniens thalamic nuclei (Re; 40%) were labeled comparably to the PVN (85%) after a retrograde tracer was injected into the RVLM/C1 (p<0.01 mean±SEM). The Re/Zi DA neuron sub-groups were characterized by angulated cell bodies, superiomedial and inferiomedial projections reaching the contralateral Re/Zi and ipsilateral PVN DA neurons respectively. Ultimately, we deduced that the dopaminergic projections of the Re/Zi to the PVN contribute to the PVN-RVLM/C1 neural circuit. As a result of these connections, the Re/Zi dopaminergic neuron groups may regulate preautonomic sympathetic events associated with the PVN-RVLM pathway.
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影响因子：
25
作者：
Stuber GD;Wise RA
通讯作者：
Wise RA
DOI：
10.1152/ajpheart.00722.2011
发表时间：
2012-04-01
影响因子：
4.8
作者：
Xu, Bo;Zheng, Hong;Patel, Kaushik P.
通讯作者：
Patel, Kaushik P.
DOI：
10.1002/cne.22283
发表时间：
2010-05-01
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Geerling JC;Shin JW;Chimenti PC;Loewy AD
通讯作者：
Loewy AD
影响因子：
9.3
作者：
Sonni, Ida;Fazio, Patrik;Varrone, Andrea
通讯作者：
Varrone, Andrea
影响因子：
5.6
作者：
Shell, Brent;Faulk, Katelynn;Cunningham, J. Thomas
通讯作者：
Cunningham, J. Thomas