Paraventricular hypothalamic nucleus: axonal projections to the brainstem.
Paraventricular hypothalamic nucleus: axonal projections to the brainstem.
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DOI：
10.1002/cne.22283
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发表时间：
2010-05-01
期刊：
影响因子：
--
通讯作者：
Loewy AD
中科院分区：
文献类型：
--
作者：
Geerling JC;Shin JW;Chimenti PC;Loewy AD
下丘脑室旁核（PVH）包含许多神经元，支配脑干，但有关其靶点的信息仍然不完整。在这里，我们用顺行轴突示踪剂标记大鼠PVH中的神经元，菜豆白细胞凝集素（PHAL），并研究了它们在整个脑干中特定神经元亚群的下行投射。虽然以前已经确定了许多目标地点，但提出了许多新的意见。主要调查结果包括：（1）在中脑，PVH轻投射至腹侧被盖区、Edinger-Westphal核、腹外侧导水管周围灰质、网状结构、脚桥被盖核和中缝背核。(2)在脑桥背侧，PVH主要投射到蓝斑前核，而很少投射到蓝斑内的儿茶酚胺神经元，并选择性地投射到臂旁核的内脏感觉亚区;（3）延髓腹侧有上级泌涎核、小斜方后核、疑核致密结构和外侧结构、A1和C1尾侧的儿茶酚胺神经元，（4）孤束内侧核（包括A2去甲肾上腺素能神经元和醛固酮敏感神经元）接受PVH最广泛的投射，远多于迷走背核或最后区。我们的研究结果表明，PVH可以调节一系列的稳态功能，包括脑和眼血流，角膜和鼻水合作用，摄食行为，钠摄入量和葡萄糖代谢，以及心血管，胃肠道和呼吸活动。
The paraventricular hypothalamic nucleus (PVH) contains many neurons that innervate the brainstem, but information regarding their target sites remains incomplete. Here, we labeled neurons in the rat PVH with an anterograde axonal tracer, Phaseolus vulgaris leucoagglutinin (PHAL) and studied their descending projections in reference to specific neuronal subpopulations throughout the brainstem. While many of their target sites were identified previously, numerous new observations were made. Major findings include: (1) In the midbrain, the PVH projects lightly to the ventral tegmental area, Edinger-Westphal nucleus, ventrolateral periaqueductal gray matter, reticular formation, pedunculopontine tegmental nucleus, and dorsal raphe nucleus. (2) In the dorsal pons, the PVH projects heavily to the pre-locus coeruleus, yet very little to the catecholamine neurons in the locus coeruleus, and selectively targets the viscerosensory subregions of the parabrachial nucleus; (3) In the ventral medulla, the superior salivatory nucleus, retrotrapezoid nucleus, compact and external formations of the nucleus ambiguus, A1 and caudal C1 catecholamine neurons, and caudal pressor area receive dense axonal projections, generally exceeding the PVH projection to the rostral C1 region; (4) The medial nucleus of the solitary tract (including A2 noradrenergic and aldosterone-sensitive neurons) receives the most extensive projections of the PVH, substantially more than the dorsal vagal nucleus or area postrema. Our findings suggest that the PVH may modulate a range of homeostatic functions, including cerebral and ocular blood flow, corneal and nasal hydration, ingestive behavior, sodium intake, and glucose metabolism, as well as cardiovascular, gastrointestinal, and respiratory activities.
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影响因子：
4.5
作者：
BANKS, D;HARRIS, MC
通讯作者：
HARRIS, MC
影响因子：
2.5
作者：
BYRUM, CE;GUYENET, PG
通讯作者：
GUYENET, PG
影响因子：
2.5
作者：
CONTRERAS, RJ;GOMEZ, MM;NORGREN, R
通讯作者：
NORGREN, R
DOI：
10.1001/archneurpsyc.1932.02240060016002
发表时间：
1932-12-01
影响因子：
--
作者：
Chorobski, J;Penfield, W
通讯作者：
Penfield, W
DOI：
10.1111/j.1440-1681.1996.tb02590.x
发表时间：
1996-02-01
影响因子：
2.9
作者：
Blair, ML;Piekut, D;Olschowka, JA
通讯作者：
Olschowka, JA