Magnetic kyphoplasty: A novel drug delivery system for the spinal column.
Magnetic kyphoplasty: A novel drug delivery system for the spinal column.
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DOI：
10.1371/journal.pone.0201402
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Mehta AI
中科院分区：
文献类型：
--
作者：
Denyer S;Bhimani AD;Papastefan S;Kheirkhah P;Aguilar T;Zakrzewski J;Rosinski CL;Patel AS;Patel S;Zakrzewski V;Seksenyan A;Prins GS;Mehta AI
由转移性恶性肿瘤或骨质疏松症引起的椎体压缩性骨折（VCF）是一种破坏性损伤，对患者具有衰弱的结局。微创椎体后凸成形术是用于症状改善的常用手术。然而，它未能治疗VCF的潜在病因。由于脊柱灌注低和全身毒性，全身治疗的使用受到限制。将药物局部递送至脊柱可以提供有希望的替代方法。建立了一个猪椎体后凸成形术模型，以研究全身注射磁性纳米颗粒（MNP）的磁性引导药物递送。将Jamshidi空心椎弓根针置入胸椎，在可膨胀骨成型球囊扩张后，将磁性骨水泥注入椎体。在静脉内注射MNP后进行组织学分析。采集组织的定性分析显示磁性骨水泥成功植入椎体。对几个椎体组织切片的进一步定量分析表明，与未注射磁性骨水泥的区域相比，在椎体后凸成形术期间注射磁性骨水泥的区域MNP积聚增强。通过修改椎体后凸成形术骨水泥，包括磁铁，从而提供了一个指导刺激和定位器，我们成功地引导静脉注射的磁性纳米粒子到胸椎。这些结果证明了一种新的药物递送策略的概念的体内证明，该策略除了提供症状支持外，还具有治疗VCF的根本原因的潜力。
Vertebral compression fractures (VCFs) caused by metastatic malignancies or osteoporosis are devastating injuries with debilitating outcomes for patients. Minimally invasive kyphoplasty is a common procedure used for symptomatic amelioration. However, it fails in treating the underlying etiologies of VCFs. Use of systemic therapy is limited due to low perfusion to the spinal column and systemic toxicity. Localized delivery of drugs to the vertebral column can provide a promising alternative approach. A porcine kyphoplasty model was developed to study the magnetically guided drug delivery of systemically injected magnetic nanoparticles (MNPs). Jamshidi cannulated pedicle needles were placed into the thoracic vertebra and, following inflatable bone tamp expansion, magnetic bone cement was injected to the vertebral body. Histological analysis was performed after intravenous injection of MNPs. Qualitative analysis of harvested tissues revealed successful placement of magnetic cement into the vertebral body. Further quantitative analysis of histological sections of several vertebral bodies demonstrated enhanced accumulation of MNPs to regions that had magnetic cement injected during kyphoplasty compared to those that did not. By modifying the kyphoplasty bone cement to include magnets, thereby providing a guidance stimulus and a localizer, we were successfully able to guide intravenously injected magnetic nanoparticles to the thoracic vertebra. These results demonstrate an in-vivo proof of concept of a novel drug delivery strategy that has the potential to treat the underlying causes of VCFs, in addition to providing symptomatic support.
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DOI：
10.1016/j.msec.2016.09.052
发表时间：
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
Nanomaterials (Basel, Switzerland)
影响因子：
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作者：
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DOI：
10.1080/09205063.2017.1414482
发表时间：
2018-01-01
影响因子：
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作者：
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影响因子：
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Pioletti, D. P.