Magnetic Nanoparticles: From Design and Synthesis to Real World Applications.
Magnetic Nanoparticles: From Design and Synthesis to Real World Applications.
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DOI：
10.3390/nano7090243
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发表时间：
2017-08-29
期刊：
影响因子：
--
通讯作者：
Zitka O
中科院分区：
文献类型：
--
作者：
Kudr J;Haddad Y;Richtera L;Heger Z;Cernak M;Adam V;Zitka O
越来越多的科学出版物专注于磁性材料，这表明更广泛的科学界越来越感兴趣。在合成所需尺寸、形态、化学组成和表面化学的磁性材料方面取得了实质性进展。磁性材料的物理和化学稳定性通过涂层获得。此外，可以设计聚合物、二氧化硅、生物分子等的表面层以获得对靶分子的亲和力。对外部磁场的响应能力和涂层的丰富可能性的结合使得磁性材料成为小分子、生物分子和细胞磁性分离的通用工具。在生物医学领域，磁性颗粒和磁性复合材料被用作药物载体，用作磁共振成像（MRI）的造影剂，以及用于磁热疗。然而，能够同时进行诊断和治疗的多功能磁性颗粒正在出现。介绍的综述文章总结了有关磁性材料的设计和合成的研究结果集中在生物医学应用。我们强调了磁性材料在分离/预浓缩各种分子和细胞中的应用，以及它们在诊断和治疗中的应用。
The increasing number of scientific publications focusing on magnetic materials indicates growing interest in the broader scientific community. Substantial progress was made in the synthesis of magnetic materials of desired size, morphology, chemical composition, and surface chemistry. Physical and chemical stability of magnetic materials is acquired by the coating. Moreover, surface layers of polymers, silica, biomolecules, etc. can be designed to obtain affinity to target molecules. The combination of the ability to respond to the external magnetic field and the rich possibilities of coatings makes magnetic materials universal tool for magnetic separations of small molecules, biomolecules and cells. In the biomedical field, magnetic particles and magnetic composites are utilized as the drug carriers, as contrast agents for magnetic resonance imaging (MRI), and in magnetic hyperthermia. However, the multifunctional magnetic particles enabling the diagnosis and therapy at the same time are emerging. The presented review article summarizes the findings regarding the design and synthesis of magnetic materials focused on biomedical applications. We highlight the utilization of magnetic materials in separation/preconcentration of various molecules and cells, and their use in diagnosis and therapy.
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