Differences in atheroma between Caucasian and Asian subjects with anterior stroke: A vessel wall MRI study.
Differences in atheroma between Caucasian and Asian subjects with anterior stroke: A vessel wall MRI study.
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高加索和亚洲前壁卒中患者动脉粥样硬化的差异：血管壁MRI研究
DOI：
10.1136/svn-2020-000370
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发表时间：
2021-03
影响因子：
5.9
通讯作者：
Hatsukami TS
中科院分区：
文献类型：
--
作者：
Watase H;Shen M;Sui B;Gao P;Zhang D;Sun J;Balu N;Hippe DS;Jarvik GP;Zhao X;Li R;Chen S;Yuan C;Hatsukami TS
虽然颅外颈动脉狭窄在高加索人中更常见，而颅内动脉狭窄在亚洲人中更常见，但动脉粥样硬化斑块特征的差异尚未得到广泛研究。我们试图利用血管壁MRI研究有症状的高加索人和中国人颅外颈动脉和颅内动脉内斑块的位置和特征。招募近期发生前循环缺血性卒中的受试者，并在美国和中国的两个研究中心使用相似方案进行成像。对颅外颈动脉和颅内动脉进行了检查，以确定斑块的位置和特征。高加索人和中国人颅外颈动脉斑块的患病率分别为73.1%和49.1%（p=0.055）。高加索人和中国人的颅内斑块患病率分别为38.5%和69.1%（p=0.02）。此外，42%的白人和16%的中国人在颅外颈动脉中具有高危斑块（HRP）特征（斑块内出血，管腔表面破裂）（p=0.03）。两个队列之间颅内动脉HRP特征的患病率无显著差异（4% vs 11%; p=0.42）。通过血管壁MRI确定近期前循环缺血性卒中的美国白人和中国受试者脑血管动脉粥样硬化的位置和特征的差异。具有HRP特征的颅外颈动脉斑块在白种人中更常见。颅内斑块在中国受试者中更常见，但两个队列的颅内HRP患病率无显着差异。使用血管壁成像研究脑血管疾病的种族差异的大型研究可能会告知HRP发展的潜在机制，并最终可能有助于指导适当的治疗。
While extracranial carotid artery stenosis is more common among Caucasians and intracranial artery stenosis is more common among Asians, the differences in atherosclerotic plaque characteristics have not yet been extensively examined. We sought to investigate plaque location and characteristics within extracranial carotid and intracranial arteries in symptomatic Caucasians and Chinese using vessel wall MRI. Subjects with recent anterior circulation ischaemic stroke were recruited and imaged at two sites in the USA and China using similar protocols. Both extracranial carotid and intracranial arteries were reviewed to determine plaque location and characteristics. The prevalence of extracranial carotid plaque in Caucasians and Chinese was 73.1% and 49.1%, respectively (p=0.055). Prevalence of intracranial plaque was 38.5% and 69.1% in Caucasians and Chinese, respectively (p=0.02). Furthermore, 42% of Caucasians and 16% of Chinese had high-risk plaque (HRP) features (intraplaque haemorrhage, luminal surface disruption) in the extracranial carotid artery (p=0.03). The prevalence of HRP features in intracranial arteries was not significantly different between the two cohorts (4% vs 11%; p=0.42). Differences in the location and characteristics of cerebrovascular atherosclerosis were identified by vessel wall MRI in US Caucasian and Chinese subjects with recent anterior circulation ischaemic stroke. Extracranial carotid plaques with HRP features were more common in Caucasians. Intracranial plaques were more common in Chinese subjects, but no significant difference between the two cohorts in intracranial HRP prevalence was found. Larger studies using vessel wall imaging to investigate racial differences in cerebrovascular disease may inform underlying mechanisms of HRP development and may ultimately help guide appropriate therapy.
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DOI：
10.1016/s0368-1319(66)80018-2
发表时间：
1966-01-01
期刊：
JOURNAL OF ATHEROSCLEROSIS RESEARCH
影响因子：
--
作者：
NAKAMURA, M;ISHIHARA, Y;YABUTA, N
通讯作者：
YABUTA, N
影响因子：
3.3
作者：
Balu, Niranjan;Yarnykh, Vasily L.;Chu, Baocheng;Wang, Jinnan;Hatsukami, Thomas;Yuan, Chun
通讯作者：
Yuan, Chun
影响因子：
8.2
作者：
Kim BJ;Kim JS
通讯作者：
Kim JS
影响因子：
8.3
作者：
Mazighi, Mikael;Labreuche, Julien;Amarenco, Pierre
通讯作者：
Amarenco, Pierre
影响因子：
8.3
作者：
Gupta, Ajay;Baradaran, Hediyeh;Sanelli, Pina C.
通讯作者：
Sanelli, Pina C.