Carotid plaque assessment using fast 3D isotropic resolution black-blood MRI.

Carotid plaque assessment using fast 3D isotropic resolution black-blood MRI.
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DOI:
10.1002/mrm.22642
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发表时间:
2011-03
影响因子:
3.3
通讯作者:
Yuan, Chun
Yuan, Chun
中科院分区:
医学3区
文献类型:
--
作者:
Balu, Niranjan;Yarnykh, Vasily L.;Chu, Baocheng;Wang, Jinnan;Hatsukami, Thomas;Yuan, Chun

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Black-blood MRI is a promising tool for carotid atherosclerotic plaque burden assessment and compositional analysis. However, current sequences are limited by large slice thickness. Accuracy of measurement can be improved by moving to isotropic imaging but can be challenging for patient compliance due to long scan times. We present a fast isotropic high spatial resolution (0.7×0.7×0.7mm) 3D black-blood sequence (3D-MERGE) covering the entire cervical carotid arteries within 2 minutes thus ensuring patient compliance and diagnostic image quality. The sequence is optimized for vessel wall imaging of the carotid bifurcation based on its signal properties. The optimized sequence is validated on patients with significant carotid plaque. Quantitative plaque morphology measurements and SNR measures show that 3D MERGE provides good blood suppression and comparable plaque burden measurements to existing MRI protocols. 3D-MERGE is a promising new tool for fast and accurate plaque burden assessment in patients with atherosclerotic plaque.
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