Non-contact identification and differentiation of illicit drugs using fluorescent films.

Non-contact identification and differentiation of illicit drugs using fluorescent films.
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使用荧光膜非接触式识别和区分违禁药物

DOI:
10.1038/s41467-018-04119-6
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发表时间:
2018-04-27
影响因子:
16.6
通讯作者:
Fang Y
Fang Y
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Liu K;Shang C;Wang Z;Qi Y;Miao R;Liu K;Liu T;Fang Y

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多年来,以非接触方式敏感和快速识别非法药物仍然是一项挑战。在这里,我们报告了三种基于薄膜的荧光传感器,它们对六种广泛滥用的非法药物,包括甲基苯丙胺(MAPA)、摇头丸、magu、咖啡因、苯巴比妥(PB)和氯胺酮,具有前所未有的灵敏度、选择性和响应速度。重要的是,对于这些药物,在室温下分别将其饱和蒸气用空气稀释5.0 × 105、4.0 × 105、2.0 × 105、1.0 × 105、4.0 × 104和2.0 × 102倍后,即可成功进行传感。此外,有气味的物质(洗漱用品、水果、脏衣服等)、水和含有氨基键的有机化合物(典型的有机胺、合法药物和不同的氨基酸)的存在对感知的影响很小。更重要的是,通过阵列方式使用传感器可以实现对它们的识别和识别。在此基础上,开发了一种概念性的、基于双传感器的检测器,实现了药物的非接触检测。以非接触方式敏感和快速识别非法药物仍然是一项挑战。在这里,作者报告了三种基于薄膜的荧光传感器对六种广泛滥用的非法药物在气相中表现出显着的灵敏度,选择性和响应速度。
Sensitive and rapid identification of illicit drugs in a non-contact mode remains a challenge for years. Here we report three film-based fluorescent sensors showing unprecedented sensitivity, selectivity, and response speed to the existence of six widely abused illicit drugs, including methamphetamine (MAPA), ecstasy, magu, caffeine, phenobarbital (PB), and ketamine in vapor phase. Importantly, for these drugs, the sensing can be successfully performed after 5.0 × 105, 4.0 × 105, 2.0 × 105, 1.0 × 105, 4.0 × 104, and 2.0 × 102 times dilution of their saturated vapor with air at room temperature, respectively. Also, presence of odorous substances (toiletries, fruits, dirty clothes, etc.), water, and amido-bond-containing organic compounds (typical organic amines, legal drugs, and different amino acids) shows little effect upon the sensing. More importantly, discrimination and identification of them can be realized by using the sensors in an array way. Based upon the discoveries, a conceptual, two-sensor based detector is developed, and non-contact detection of the drugs is realized. Sensitive and rapid identification of illicit drugs in a non-contact mode remains a challenge. Here, the authors report three film-based fluorescent sensors showing remarkable sensitivity, selectivity and response speed to six widely abused illicit drugs in vapor phase.
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