The critical roles of activated stellate cells-mediated paracrine signaling, metabolism and onco-immunology in pancreatic ductal adenocarcinoma.
The critical roles of activated stellate cells-mediated paracrine signaling, metabolism and onco-immunology in pancreatic ductal adenocarcinoma.
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活化星状细胞介导的旁分泌信号、代谢和肿瘤免疫学在胰腺导管腺癌中的关键作用
DOI：
10.1186/s12943-018-0815-z
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发表时间：
2018-02-19
期刊：
影响因子：
37.3
通讯作者：
Shen H
中科院分区：
文献类型：
--
作者：
Fu Y;Liu S;Zeng S;Shen H
胰腺导管腺癌（Pancreatic ductal adenocarcinoma，PDAC）是世界范围内致死率最高的恶性肿瘤之一。它是传统治疗难治性的，因此有记录的5年生存率低至7%。越来越多的证据表明，活化的胰腺星状细胞（PSC）作为肿瘤微环境（TME）的基质成分之一，在PDAC的促结缔组织增生、癌变、侵袭、转移等过程中起着重要作用。尽管目前对PSC的理解是PDAC的“犯罪伙伴”，但PSC和相关微环境的详细调控作用仍然不清楚。除了多种旁分泌信号通路外，最近的研究证实PSC介导的肿瘤微环境可能通过多种机制影响PDAC的行为，如重新连接代谢网络、抑制免疫反应等。这些新的活性与PDAC的治疗和预后密切相关。本文就活化PSC的新功能，包括PSC与癌细胞的相互作用、免疫抑制调节机制和代谢重编程等方面的最新研究进展作一综述。很明显，这些最新的PSC实验或临床研究可能在不久的将来为PDAC治疗提供有希望的方法。
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant diseases worldwide. It is refractory to conventional treatments, and consequently has a documented 5-year survival rate as low as 7%. Increasing evidence indicates that activated pancreatic stellate cells (PSCs), one of the stromal components in tumor microenvironment (TME), play a crucial part in the desmoplasia, carcinogenesis, aggressiveness, metastasis associated with PDAC. Despite the current understanding of PSCs as a “partner in crime” to PDAC, detailed regulatory roles of PSCs and related microenvironment remain obscure. In addition to multiple paracrine signaling pathways, recent research has confirmed that PSCs-mediated tumor microenvironment may influence behaviors of PDAC via diverse mechanisms, such as rewiring metabolic networks, suppressing immune responses. These new activities are closely linked with treatment and prognosis of PDAC. In this review, we discuss the recent advances regarding new functions of activated PSCs, including PSCs-cancer cells interaction, mechanisms involved in immunosuppressive regulation, and metabolic reprogramming. It’s clear that these updated experimental or clinical studies of PSCs may provide a promising approach for PDAC treatment in the near future.
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DOI：
10.1083/jcb.201701064
发表时间：
2017-12-04
期刊：
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影响因子：
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期刊：
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10.1016/j.pan.2016.05.393
发表时间：
2016-11
期刊：
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
影响因子：
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通讯作者：
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