Hair organ regeneration via the bioengineered hair follicular unit transplantation.
Hair organ regeneration via the bioengineered hair follicular unit transplantation.
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DOI：
10.1038/srep00424
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发表时间：
2012
影响因子：
4.6
通讯作者：
Tsuji, Takashi
中科院分区：
文献类型：
--
作者：
Asakawa, Kyosuke;Toyoshima, Koh-ei;Ishibashi, Naoko;Tobe, Hirofumi;Iwadate, Ayako;Kanayama, Tatsuya;Hasegawa, Tomoko;Nakao, Kazuhisa;Toki, Hiroshi;Noguchi, Shotaro;Ogawa, Miho;Sato, Akio;Tsuji, Takashi
器官再生疗法旨在再生功能完备的器官，以替代因疾病、损伤或衰老而丧失或受损的器官。对于外胚层器官的功能完备再生，有人提出了一个概念，即通过重现器官发生的胚胎过程来开发一种生物工程器官。在此，我们表明，用胚胎皮肤来源的上皮细胞和间充质细胞重组并异位移植的生物工程毛囊胚芽，能够发育出组织学上正确的毛囊。通过皮内移植，生物工程毛囊与宿主皮肤上皮正确连接，并重现了干细胞微环境和毛发周期。生物工程毛囊还在永久性区域自主地与神经和立毛肌连接，并表现出竖毛能力。我们的研究结果表明，生物工程毛囊能够恢复生理性毛发功能，并可应用于脱发的手术治疗。
Organ regenerative therapy aims to reproduce fully functional organs to replace organs that have been lost or damaged as a result of disease, injury, or aging. For the fully functional regeneration of ectodermal organs, a concept has been proposed in which a bioengineered organ is developed by reproducing the embryonic processes of organogenesis. Here, we show that a bioengineered hair follicle germ, which was reconstituted with embryonic skin-derived epithelial and mesenchymal cells and ectopically transplanted, was able to develop histologically correct hair follicles. The bioengineered hair follicles properly connected to the host skin epithelium by intracutaneous transplantation and reproduced the stem cell niche and hair cycles. The bioengineered hair follicles also autonomously connected with nerves and the arrector pili muscle at the permanent region and exhibited piloerection ability. Our findings indicate that the bioengineered hair follicles could restore physiological hair functions and could be applicable to surgical treatments for alopecia.
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肝组织工程：从移植到实验室定制的基于细胞的肝脏定向疗法。
影响因子：
5.3
作者：
Fiegel HC;Kaufmann PM;Bruns H;Kluth D;Horch RE;Vacanti JP;Kneser U
通讯作者：
Kneser U
影响因子：
64.5
作者：
Fujiwara H;Ferreira M;Donati G;Marciano DK;Linton JM;Sato Y;Hartner A;Sekiguchi K;Reichardt LF;Watt FM
通讯作者：
Watt FM
影响因子：
3.7
作者：
Oshima M;Mizuno M;Imamura A;Ogawa M;Yasukawa M;Yamazaki H;Morita R;Ikeda E;Nakao K;Takano-Yamamoto T;Kasugai S;Saito M;Tsuji T
通讯作者：
Tsuji T
影响因子：
23.9
作者：
Brownell, Isaac;Guevara, Elizabeth;Bai, C. Brian;Loomis, Cynthia A.;Joyner, Alexandra L.
通讯作者：
Joyner, Alexandra L.
影响因子：
48
作者：
Nakao, Kazuhisa;Morita, Ritsuko;Tsuji, Takashi
通讯作者：
Tsuji, Takashi