Functional tooth regeneration using a bioengineered tooth unit as a mature organ replacement regenerative therapy.
Functional tooth regeneration using a bioengineered tooth unit as a mature organ replacement regenerative therapy.
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DOI：
10.1371/journal.pone.0021531
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Tsuji T
中科院分区：
文献类型：
--
作者：
Oshima M;Mizuno M;Imamura A;Ogawa M;Yasukawa M;Yamazaki H;Morita R;Ikeda E;Nakao K;Takano-Yamamoto T;Kasugai S;Saito M;Tsuji T
供体器官移植目前是体内因疾病、损伤或衰老导致器官功能失调时进行替代的一种重要治疗方法。再生治疗领域的最新进展有可能在未来实现生物工程化的成熟器官替代。在这项概念验证研究中，我们在此报告了这方面的进一步发展：在一个小鼠移植模型系统中，通过受体骨重塑实现骨整合，一个包含成熟牙齿、牙周韧带和牙槽骨的生物工程牙齿单元被成功移植到牙槽骨中一个大小合适的骨洞中。生物工程牙齿单元在垂直方向上使牙槽骨在小鼠下颌的大面积骨缺损中得到了充分修复。植入的生物工程牙齿显示出诸如咀嚼、牙周韧带对骨重塑的作用以及对有害刺激的反应等生理牙齿功能。因此，这项研究代表了一项重大进展，并展示了生物工程化成熟器官替代作为下一代再生治疗的真正潜力。
Donor organ transplantation is currently an essential therapeutic approach to the replacement of a dysfunctional organ as a result of disease, injury or aging in vivo. Recent progress in the area of regenerative therapy has the potential to lead to bioengineered mature organ replacement in the future. In this proof of concept study, we here report a further development in this regard in which a bioengineered tooth unit comprising mature tooth, periodontal ligament and alveolar bone, was successfully transplanted into a properly-sized bony hole in the alveolar bone through bone integration by recipient bone remodeling in a murine transplantation model system. The bioengineered tooth unit restored enough the alveolar bone in a vertical direction into an extensive bone defect of murine lower jaw. Engrafted bioengineered tooth displayed physiological tooth functions such as mastication, periodontal ligament function for bone remodeling and responsiveness to noxious stimulations. This study thus represents a substantial advance and demonstrates the real potential for bioengineered mature organ replacement as a next generation regenerative therapy.
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