Viral and cellular messenger RNA targets of viral microRNAs.
Viral and cellular messenger RNA targets of viral microRNAs.
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DOI：
10.1038/nature07757
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发表时间：
2009-01-22
期刊：
影响因子：
64.8
通讯作者：
Cullen, Bryan R.
中科院分区：
文献类型：
--
作者：
Cullen, Bryan R.
考虑到病毒为了自身利益而选择细胞途径和活动的倾向，现在已经显示出几种病毒也使用病毒编码的microRNA来重塑细胞环境以使其受益，这也许并不奇怪。具体地，微小RNA由病毒病原体的疱疹病毒家族的各种成员在其复制周期的潜伏期和生产期两者期间表达。新出现的数据表明，病毒miRNA可能是特别重要的调节从潜伏到裂解复制的过渡，并减弱潜在的抑制性宿主抗病毒免疫反应。
Given the propensity of viruses to co-opt cellular pathways and activities for their own benefit, it is perhaps not surprising that several viruses have now also been shown to use virally encoded microRNAs to reshape the cellular environment to their benefit. In particular, microRNAs are expressed by the various members of the herpesvirus family of viral pathogens during both the latent and productive phases of their replication cycles. Emerging data suggest that viral miRNAs may be particularly important for regulating the transition from latent to lytic replication and for attenuating potentially inhibitory host antiviral immune responses.
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