Modulation of the immune response to Listeria monocytogenes by benzene inhalation.
Modulation of the immune response to Listeria monocytogenes by benzene inhalation.
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通过吸入苯调节对单核细胞增生李斯特氏菌的免疫反应。
DOI：
10.1016/0041-008x(85)90395-3
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发表时间：
1985
影响因子：
3.8
通讯作者：
Snyder,CA
中科院分区：
文献类型：
--
作者：
Rosenthal,GJ;Snyder,CA
苯是一种强效的骨髓毒物。虽然所有类型的血细胞都是苯中毒的目标，但淋巴细胞尤其敏感。苯或其代谢物的免疫毒性后果已在若干体外研究中得到证实；然而，关于苯对宿主对感染因子的抗性的影响的数据很少。本研究考察了苯对小鼠对感染性病原体单核细胞增生李斯特菌的抗性的影响。使用了四种浓度的苯，10、30、100和300 ppm。为了确定苯影响的恢复情况，采用了两种暴露方案：感染前5天（暴露前），或感染前5天和感染期间7天（持续暴露）。保持适当的空气管制。在感染后第1、4和7天，测定小鼠脾脏细菌计数和免疫应答细胞群。在感染的第4天，仅在苯浓度最高的情况下（300 ppm），预暴露于苯时细菌数量增加。相比之下，在感染的第4天，除了最低苯浓度（10 ppm）外，持续暴露产生的细菌数量都有所增加。在感染的第1天或第7天，任何苯处理组的细菌计数均未增加。第4天细菌数量的增加表明对细胞介导的免疫反应有影响。T淋巴细胞和B淋巴细胞对苯特别敏感，在两种暴露方案中，所有浓度≥30ppm时均表现出减少。然而，酯酶阳性细胞相对抵抗苯的影响。结果表明，苯诱导的免疫反应延迟对单核细胞增生乳杆菌。
Benzene is a potent bone marrow toxicant. While all blood cell types are targets for benzene poisoning, lymphocytes are particularly sensitive. The immunotoxic consequences of benzene or its metabolites have been demonstrated in a number of in vitro studies; however, little data exist regarding the effects of benzene on host resistance to infectious agents. This investigation examined the effects of benzene on murine resistance to an infectious agent, Listeria monocytogenes. Four concentrations of benzene were employed, 10, 30, 100, and 300 ppm. To determine recovery from the effects of benzene, two exposure regimens were employed: 5 days prior to infection (preexposure), or 5 days prior to and 7 days during infection (continuous exposure). Appropriate air controls were maintained. Splenic bacterial counts and immune responsive cell populations were determined from mice killed at Days 1, 4, and 7 of infection. Preexposure to benzene produced increased bacterial numbers at Day 4 of the infection only at the highest benzene concentration (300 ppm). In contrast, continuous exposure produced increased bacterial numbers at Day 4 of infection at all but the lowest benzene concentration (10 ppm). Bacteria counts were not increased in any benzene-treated group at Day 1 or Day 7 of infection. The increased bacterial numbers at Day 4 suggest an effect on cell-mediated immune responses. Both T and B lymphocytes were particularly sensitive to benzene exhibiting reductions at all concentrations ≥ 30 ppm for both exposure regimens. Esterase-positive cells, however, were relatively resistant to benzenes effects. The results point to a benzene-induced delay in the immune response to L. monocytogenes.
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暴露于低浓度苯的小鼠中，B 淋巴细胞和 T 淋巴细胞有丝分裂原诱导的胚芽发育受到抑制。
影响因子：
3.5
作者：
Rozen,MG;Snyder,CA;Albert,RE
通讯作者：
Albert,RE
颗粒物质引起的炎症反应早期阶段单核细胞生成的体液调节。
影响因子：
20.3
作者：
D. van Waarde;E. Hulsing;L. Sandkuyl;R. van Furth
通讯作者：
R. van Furth
两种内源性因素对单核细胞前体细胞增殖的调节。
影响因子：
2.8
作者：
W. Sluiter;D. van Waarde;R. van Furth
通讯作者：
R. van Furth
吞噬细胞对单核细胞增生李斯特菌抵抗力的三个阶段。
DOI：
10.1099/00221287-106-1-165
发表时间：
1978
期刊：
Journal of general microbiology
影响因子：
--
作者：
M. Mitsuyama;K. Takeya;K. Nomoto;S. Shimotori
通讯作者：
S. Shimotori
吸入苯对CD-1雄性小鼠外周血、骨髓和脾细胞的急性和慢性剂量/反应影响。
影响因子：
3.8
作者：
J. D. Green;C. Snyder;J. Lobue;B. Goldstein;R. Albert
通讯作者：
R. Albert