Axon density and axon orientation dispersion in children born preterm.
Axon density and axon orientation dispersion in children born preterm.
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DOI：
10.1002/hbm.23227
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发表时间：
2016-09
影响因子：
4.8
通讯作者：
Anderson PJ
中科院分区：
文献类型：
--
作者：
Kelly CE;Thompson DK;Chen J;Leemans A;Adamson CL;Inder TE;Cheong JL;Doyle LW;Anderson PJ
极早产（VPT，<32周妊娠）与改变的白色物质各向异性分数（FA）相关，其生物学基础尚不确定，但可能与轴突密度和/或分散的变化有关，可以使用神经突方向分散和密度成像（NODDI）进行测量。我们的目的是比较VPT儿童和对照组（出生时妊娠≥37周）的全脑白色FA、轴突离散度和轴突密度，并调查与围产期因素和神经发育结局的相关性。FA，神经突分散和神经突密度估计从多壳扩散磁共振图像为145 VPT和33个控制7岁的孩子。使用基于区域的空间统计比较各组之间的弥散值，并将其与围产期因素（胎龄、出生体重和新生儿脑异常）和神经发育结局（IQ、运动、学术和行为结局）相关。与对照组相比，VPT儿童在许多主要的白色纤维束内具有较低的FA和较高的轴突分散度。新生儿脑异常预测较低的FA和较高的轴突离散度在许多主要的管道VPT儿童。在VPT儿童中，各神经束中FA较低、轴突分散度较高和轴突密度较低与神经发育结果较差相关。FA和NODDI测量区分VPT儿童与对照组，并与围产期医疗并发症和功能结局相关。这项研究提供了一个更详细的和生物学意义的解释白色物质的微观结构变化与早产。
Very preterm birth (VPT, <32 weeks’ gestation) is associated with altered white matter fractional anisotropy (FA), the biological basis of which is uncertain but may relate to changes in axon density and/or dispersion, which can be measured using Neurite Orientation Dispersion and Density Imaging (NODDI). We aimed to compare whole brain white matter FA, axon dispersion and axon density between VPT children and controls (born ≥37 weeks’ gestation), and to investigate associations with perinatal factors and neurodevelopmental outcomes. FA, neurite dispersion and neurite density were estimated from multi-shell diffusion magnetic resonance images for 145 VPT and 33 control 7-year-olds. Diffusion values were compared between groups and correlated with perinatal factors (gestational age, birthweight and neonatal brain abnormalities) and neurodevelopmental outcomes (IQ, motor, academic and behavioral outcomes) using Tract-Based Spatial Statistics. Compared with controls, VPT children had lower FA and higher axon dispersion within many major white matter fiber tracts. Neonatal brain abnormalities predicted lower FA and higher axon dispersion in many major tracts in VPT children. Lower FA, higher axon dispersion and lower axon density in various tracts correlated with poorer neurodevelopmental outcomes in VPT children. FA and NODDI measures distinguished VPT children from controls and were associated with perinatal medical complications and functional outcomes. This study provides a more detailed and biologically meaningful interpretation of white matter microstructure changes associated with prematurity.
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