Perspectives on the RNA polymerase II core promoter.
Perspectives on the RNA polymerase II core promoter.
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DOI：
10.1002/wdev.21
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发表时间：
2012-01
影响因子：
--
通讯作者：
Kadonaga, James T.
中科院分区：
文献类型：
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作者：
Kadonaga, James T.
RNA聚合酶II核心启动子有时被称为转录的门户。核心启动子通常被定义为指导转录起始的DNA片段。这个简单的描述掩盖了一个复杂的多维调控元件，因为核心启动子结构和功能有相当大的多样性。核心启动子可以在DNA序列、转录因子和生物网络的水平上观察。关键DNA序列被称为核心启动子元件，其包括TATA盒、起始子（Inr）、TCT、BRE、MTE和DPE基序。不存在于所有启动子中的通用核心启动子元件。不同类型的核心启动子由不同组的转录因子转录，并表现出不同的性质，如与转录增强子的特异性相互作用，这取决于特定核心启动子基序的存在或不存在。此外，已经发现一些核心启动子元件与特定的生物网络相关。例如，TCT基序专门用于果蝇和人类中核糖体蛋白基因的转录。此外，几乎所有的果蝇Hox基因在其核心启动子中都有一个DPE基序。核心启动子的复杂性进一步表现在转录起始模式、转录状态的稳定性或不稳定性以及启动子区域中染色质结构的组织之间的关系中。因此，目前的数据表明，核心启动子是基因活性调控的关键组成部分。
The RNA polymerase II core promoter is sometimes referred to as the gateway to transcription. The core promoter is generally defined to be the stretch of DNA that directs the initiation of transcription. This simple description belies a complex multidimensional regulatory element, as there is considerable diversity in core promoter structure and function. Core promoters can be viewed at the levels of DNA sequences, transcription factors, and biological networks. Key DNA sequences are known as core promoter elements, which include the TATA box, initiator (Inr), TCT, BRE, MTE, and DPE motifs. There are no universal core promoter elements that are present in all promoters. Different types of core promoters are transcribed by different sets of transcription factors and exhibit distinct properties, such as specific interactions with transcriptional enhancers, that are determined by the presence or absence of particular core promoter motifs. Moreover, some core promoter elements have been found to be associated with specific biological networks. For instance, the TCT motif is dedicated to the transcription of ribosomal protein genes in Drosophila and humans. In addition, nearly all of the Drosophila Hox genes have a DPE motif in their core promoters. The complexity of the core promoter is further seen in the relation among transcription initiation patterns, the stability or lability of transcriptional states, and the organization of the chromatin structure in the promoter region. Hence, the current data indicate that the core promoter is a critical component in the regulation of gene activity.
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影响因子：
2.7
作者：
Juven-Gershon, Tamar;Kadonaga, James T.
通讯作者：
Kadonaga, James T.
DOI：
10.1038/nrg2847
发表时间：
2010-08
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
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影响因子：
10.5
作者：
Butler, JEF;Kadonaga, JT
通讯作者：
Kadonaga, JT
影响因子：
10.5
作者：
Gazdag, Emese;Santenard, Angele;Torres-Padilla, Maria-Elena
通讯作者：
Torres-Padilla, Maria-Elena
影响因子：
64.8
作者：
通讯作者：
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