Factors associated with variability in the melatonin suppression response to light: A narrative review
Factors associated with variability in the melatonin suppression response to light: A narrative review
复制标题
与褪黑激素抑制光反应变异性相关的因素：叙述性回顾
DOI：
10.1080/07420528.2023.2188091
复制
发表时间：
2023
影响因子：
2.8
通讯作者：
E. McGlashan
中科院分区：
文献类型：
--
作者：
Carolyn B. Swope;Shengliang Rong;C. Campanella;R. Vaicekonyte;A. Phillips;S. Cain;E. McGlashan
摘要 光是使昼夜节律与 24 小时明暗周期同步的主要环境信号。最近的研究发现，昼夜节律系统对光的敏感性存在显着的个体差异，通过光响应褪黑激素抑制等指标来测量。这些个体间光敏感度的差异可能会导致昼夜节律紊乱的不同脆弱性以及对健康的相关影响。越来越多的实验证据指出了与褪黑激素抑制反应的变异性相关的特定因素。然而，迄今为止还没有任何评论对这项研究进行总结，以全面总结当前的知识。本次综述的目的是概述这一证据的状态，迄今为止涵盖人口、环境、健康相关和遗传特征。总体而言，我们发现，尽管对许多因素的研究仍然有限，但大多数所检查的特征都存在个体间差异的证据。了解与光敏感性相关的个体因素可以为改善照明个性化提供信息，以及使用光敏感性测量来确定疾病表型和治疗建议。
ABSTRACT Light is the main environmental signal synchronizing circadian rhythms to the 24-hour light-dark cycle. Recent research has identified significant inter-individual variability in the sensitivity of the circadian system to light as measured by, among other indicators, melatonin suppression in response to light. These inter-individual differences in light sensitivity could result in differential vulnerability to circadian disruption and related impacts on health. A growing body of experimental evidence points to specific factors which are associated with variability in the melatonin suppression response; however, no review to date has summarized this research to present a comprehensive summary of current knowledge. The aim of this review is to provide an overview of the state of this evidence, which to date spans demographic, environmental, health-related, and genetic characteristics. Overall, we find that there is evidence of inter-individual differences for the majority of the characteristics examined, although research on many factors remains limited. Knowledge of individual factors that are linked to light sensitivity could inform improved lighting personalization, as well as the use of measures of light sensitivity to determine disease phenotypes and treatment recommendations.
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影响因子：
5.8
作者：
Crowley, Stephanie J.;Cain, Sean W.;Carskadon, Mary A.
通讯作者：
Carskadon, Mary A.
影响因子：
26.1
作者：
Carter B;Rees P;Hale L;Bhattacharjee D;Paradkar MS
通讯作者：
Paradkar MS
DOI：
10.1056/nejmra1802337
发表时间：
2021-02-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Allada R;Bass J
通讯作者：
Bass J
影响因子：
5.8
作者：
Lockley, SW;Brainard, GC;Czeisler, CA
通讯作者：
Czeisler, CA
影响因子：
5.6
作者：
Buysse, Daniel J.
通讯作者：
Buysse, Daniel J.