Pseudogene-derived lncRNAs: emerging regulators of gene expression.
Pseudogene-derived lncRNAs: emerging regulators of gene expression.
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DOI：
10.3389/fgene.2014.00476
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发表时间：
2014
影响因子：
3.7
通讯作者：
Lipovich L
中科院分区：
文献类型：
--
作者：
Milligan MJ;Lipovich L
在人类基因组计划完成后的十多年中，人类基因组中非蛋白质编码功能元件的流行已经成为后基因组生物学的关键启示。由ENCODE（DNA元件百科全书）和FANTOM（哺乳动物功能注释）财团强调，这些元件包括数万个假基因，以及大量的长非编码RNA（lncRNA）基因。假基因的转录和功能仍然没有得到充分的理解。然而，由于假基因与其亲本蛋白质编码基因之间的高度序列相似性，该领域对人类疾病非常重要，这产生了序列特异性调控的潜力。最近的案例研究已经确立了假基因和lncRNA在后生动物系统的发育和疾病中的重要和协调作用，包括lncRNA在假基因位点的转录对假基因的亲本基因的调节的功能影响。本文综述了lncRNA和假基因在人类疾病中共同发挥作用的调控方式的新生证据，以及这些系统的最近进化起源。
In the more than one decade since the completion of the Human Genome Project, the prevalence of non-protein-coding functional elements in the human genome has emerged as a key revelation in post-genomic biology. Highlighted by the ENCODE (Encyclopedia of DNA Elements) and FANTOM (Functional Annotation of Mammals) consortia, these elements include tens of thousands of pseudogenes, as well as comparably numerous long non-coding RNA (lncRNA) genes. Pseudogene transcription and function remain insufficiently understood. However, the field is of great importance for human disease due to the high sequence similarity between pseudogenes and their parental protein-coding genes, which generates the potential for sequence-specific regulation. Recent case studies have established essential and coordinated roles of both pseudogenes and lncRNAs in development and disease in metazoan systems, including functional impacts of lncRNA transcription at pseudogene loci on the regulation of the pseudogenes’ parental genes. This review synthesizes the nascent evidence for regulatory modalities jointly exerted by lncRNAs and pseudogenes in human disease, and for recent evolutionary origins of these systems.
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影响因子：
56.9
作者：
Carninci, P;Kasukawa, T;Hayashizaki, Y
通讯作者：
Hayashizaki, Y
DOI：
10.1073/pnas.94.15.7698
发表时间：
1997-07-22
影响因子：
11.1
作者：
Gilbert, W;deSouza, SJ;Long, MY
通讯作者：
Long, MY
影响因子：
4.3
作者：
Dinger ME;Pang KC;Mercer TR;Mattick JS
通讯作者：
Mattick JS
影响因子：
56.9
作者：
Duret, L;Chureau, C;Avner, P
通讯作者：
Avner, P
人类和小鼠基因组中的复杂基因座。
影响因子：
4.5
作者：
Engstrom, Par G.;Suzuki, Harukazu;Ninomiya, Noriko;Akalin, Altuna;Sessa, Luca;Lavorgna, Giovanni;Brozzi, Alessandro;Luzi, Lucilla;Tan, Sin Lam;Yang, Liang;Kunarso, Galih;ng, Edwin Lian-Cho Ng;Batalov, Serge;Wahlestedt, Claes;Kai, Chikatoshi;Kawai, Jun;Carninci, Piero;Hayashizaki, Yoshihide;Wells, Christine;Bajic, Vladimir B.;Orlando, Valerio;Reid, James F.;Lenhard, Boris;Lipovich, Leonard
通讯作者：
Lipovich, Leonard