Coronavirus disease 2019 and peripheral blood eosinophil counts: a retrospective study.
Coronavirus disease 2019 and peripheral blood eosinophil counts: a retrospective study.
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DOI：
10.1007/s15010-021-01710-w
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发表时间：
2021-12
期刊：
影响因子：
7.5
通讯作者：
Karim F
中科院分区：
文献类型：
--
作者：
Eijmael M;Janssens N;le Cessie S;van Dooren Y;Koster T;Karim F
在COVID-19中描述了嗜酸性粒细胞减少症。通过这项研究，我们的目的是研究COVID-19患者的外周血嗜酸性粒细胞计数，并调查外周血嗜酸性粒细胞计数与COVID-19疾病严重程度之间是否存在关联。我们在荷兰豪达的Groene哈特Ziekenhuis对确诊的COVID-19患者的电子病历进行了聚合酶链反应（PCR）检测。我们根据COVID-19的临床严重程度将患者分为轻度、中度和重度组。临床严重程度基于所需的治疗和患者的结局。我们比较了三组患者的临床特征、实验室检查结果和预后。在本研究纳入的230例患者中，轻度、中度和重度组分别占纳入患者的16.5%、45.7%和37.8%。平均年龄为68岁（IQR 57 - 78）。63%的患者为男性。发现外周嗜酸性粒细胞计数显著降低，对应于COVID-19严重程度的增加。在轻度、中度和重度组中，发生嗜酸性粒细胞减少的患者百分比分别为73.7%、86.7%和94.3%（p值0.002）。严重COVID-19患者中嗜酸性粒细胞减少症的发生率明显更高。
Eosinopenia has been described in COVID-19. With this study, we aim to study the peripheral blood eosinophil counts in COVID-19 patients and to investigate whether there is an association between the peripheral blood eosinophil counts and disease severity of COVID-19. We revised the electronical medical records of confirmed COVID-19 patients with polymerase chain reaction (PCR) assays in the Groene Hart Ziekenhuis, Gouda, The Netherlands. We divided patients in mild, moderate and severe groups based on clinical severity of COVID-19. Clinical severity was based on the therapy needed and the outcome of patients. We compared clinical characteristics, laboratory results and outcome between the three groups. Of the 230 patients included in this study, the mild, moderate and severe groups consisted of 16.5%, 45.7% and 37.8% of the included patients, respectively. The mean age was 68 years (IQR 57–78). 63% of patients were male. A significant decrease in the peripheral eosinophil counts was found corresponding to the increase of COVID-19 severity. In the mild, moderate and severe groups, the percentage of patients with eosinopenia was 73.7%, 86.7% and 94.3%, respectively (p value 0.002). Eosinopenia is significantly more frequent present in patients with a severe COVID-19.
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影响因子：
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作者：
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DOI：
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