Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease.
Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease.
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DOI：
10.1111/apt.12237
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发表时间：
2013-03
影响因子：
7.6
通讯作者：
Loomba R
中科院分区：
文献类型：
--
作者：
Patel NS;Peterson MR;Brenner DA;Heba E;Sirlin C;Loomba R
非酒精性脂肪性肝病(NAFLD)患者的胰腺异位脂肪沉积及其与肝脏脂肪变性的关系以前没有被研究过。使用一种新的磁共振成像(MRI)技术对胰腺脂肪进行量化，并确定它是否与NAFLD患者的肝脏脂肪变性和/或纤维化有关。这是一项横断面研究，包括43名经活检证实为NAFLD的成人患者，他们接受了临床评估、生化测试和MRI。肝脏活检评估使用NASH-CRN组织学评分系统，肝脏和胰腺脂肪定量使用一种新的、有效的MRI生物标记物：质子密度脂肪分数。在NAFLD患者中，MRI测定的平均胰腺脂肪为8.5%，在胰头、胰体和胰尾之间没有显著差异。MRI检测的胰腺脂肪含量随着组织学判断的肝脏脂肪变性程度的增加而显著增加，1级为4.6%，2级为7.7%，3级为13.0%(P=0.004)。组织学确定的肝纤维化患者胰腺脂肪含量低于无纤维化患者(0期11.2%，1-2期5.8%，3-4期6.9%，P=0.013)。胰腺脂肪与年龄、体重指数或糖尿病状况无关。在NAFLD患者中，胰腺脂肪增加与肝脏脂肪变性有关。然而，肝纤维化与胰腺脂肪含量呈负相关。需要进一步的研究来确定潜在的机制，以了解胰腺脂肪变性是否影响NAFLD的进展。
Ectopic fat deposition in the pancreas and its association with hepatic steatosis have not previously been examined in patients with biopsy-proven non-alcoholic fatty liver disease (NAFLD). To quantify pancreatic fat using a novel magnetic resonance imaging (MRI) technique and determine whether it is associated with hepatic steatosis and/or fibrosis in patients with NAFLD. This is a cross-sectional study including 43 adult patients with biopsy-proven NAFLD who underwent clinical evaluation, biochemical testing and MRI. The liver biopsy assessment was performed using the NASH-CRN histological scoring system, and liver and pancreas fat quantification was performed using a novel, validated MRI biomarker; the proton density fat fraction. The average MRI-determined pancreatic fat in patients with NAFLD was 8.5% and did not vary significantly between head, body, and tail of the pancreas. MRI-determined pancreatic fat content increased significantly with increasing histology-determined hepatic steatosis grade; 4.6% in grade 1; 7.7% in grade 2; 13.0% in grade 3 (P = 0.004) respectively. Pancreatic fat content was lower in patients with histology-determined liver fibrosis than in those without fibrosis (11.2% in stage 0 fibrosis vs. 5.8% in stage 1–2 fibrosis, and 6.9% in stage 3–4 fibrosis, P = 0.013). Pancreatic fat did not correlate with age, body mass index or diabetes status. In patients with NAFLD, increased pancreatic fat is associated with hepatic steatosis. However, liver fibrosis is inversely associated with pancreatic fat content. Further studies are needed to determine underlying mechanisms to understand if pancreatic steatosis affects progression of NAFLD.
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影响因子：
3.3
作者：
Hernando, D.;Hines, C. D. G.;Yu, H.;Reeder, S. B.
通讯作者：
Reeder, S. B.
影响因子：
4.4
作者：
Hines, Catherine D. G.;Frydrychowicz, Alex;Hamilton, Gavin;Tudorascu, Dana L.;Vigen, Karl K.;Yu, Huanzhou;McKenzie, Charles A.;Sirlin, Claude B.;Brittain, Jean H.;Reeder, Scott B.
通讯作者：
Reeder, Scott B.
影响因子：
5
作者：
Kim, Hye Jin;Byun, Jae Ho;Lee, Moon-Gyu
通讯作者：
Lee, Moon-Gyu
影响因子：
29.4
作者：
Kotronen, Anna;Peltonen, Markku;Yki-Jarvinen, Hannele
通讯作者：
Yki-Jarvinen, Hannele
影响因子：
2.3
作者：
Bellentani, Stefano;Scaglioni, Federica;Bedogni, Giorgio
通讯作者：
Bedogni, Giorgio