MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients.
MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients.
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DOI：
10.1038/bjc.2012.80
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发表时间：
2012-04-24
影响因子：
8.8
通讯作者：
Sier, C. F. M.
中科院分区：
文献类型：
--
作者：
Langers, A. M. J.;Verspaget, H. W.;Hawinkels, L. J. A. C.;Kubben, F. J. G. M.;van Duijn, W.;van der Reijden, J. J.;Hardwick, J. C. H.;Hommes, D. W.;Sier, C. F. M.
基质金属蛋白酶MMP2和MMP9在多种癌症中的表达上调与患者的生存不良有关。我们评估了来自结直肠癌患者的正常结直肠粘膜中的基质金属蛋白酶-2和基质金属蛋白酶-9水平与病程的关系。正常胃粘膜组织中的高蛋白表达与5年生存率相关。这两个参数的组合是一个更强的预后因素。这些蛋白水平与基质金属蛋白酶-2(−1306C>；T)和基质金属蛋白酶-9(−1562C>；T)的相应单核苷酸多态性无关。多因素分析显示，正常粘膜中的基质金属蛋白酶-2和基质金属蛋白酶-9水平是影响患者生存的独立于TNM分期的预后因素。结直肠癌患者正常粘膜中的基质金属蛋白酶-2和基质金属蛋白酶-9水平可作为判断其病程的指标。
Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease. A high protein expression of MMP-2 as well as MMP-9 in normal mucosa was found to be correlated with worse 5-year survival. The combination of both parameters was an even stronger prognostic factor. These protein levels were found not to be related to the corresponding single nucleotide polymorphisms of MMP-2 (−1306C>T) and MMP-9 (−1562C>T). Multivariate analyses indicated that the MMP-2 and MMP-9 levels in normal mucosa are prognostic for survival, independent of TNM classification. MMP-2 and MMP-9 levels in normal mucosa are indicative of the course of disease in colorectal cancer patients.
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影响因子：
8.8
作者：
通讯作者：
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