Semicircular Canal Influences on the Developmental Tuning of the Translational Vestibulo-Ocular Reflex.
Semicircular Canal Influences on the Developmental Tuning of the Translational Vestibulo-Ocular Reflex.
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DOI：
10.3389/fneur.2018.00404
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发表时间：
2018
影响因子：
3.4
通讯作者：
Straka H
中科院分区：
文献类型：
--
作者：
Branoner F;Straka H
前庭眼反射 (VOR) 依赖于神经元计算，将前庭感觉信号转换为时空适当的眼外运动命令。线性平移过程中上斜眼肌收缩的运动神经元放电源自与该肌肉的拉动方向在空间上对齐的椭圆囊上皮部分。在非洲爪蟾中，这种排列是在幼虫发育过程中逐渐实现的，并且需要与运动相关的半规管传入活动。在这里，我们研究了半规管和椭圆囊信号的起源，这些信号负责眼外运动反应矢量的建立和成熟。在单侧横断第八神经之前和之后的非洲爪蟾蝌蚪半完整制剂以及在管状结构建立之前通过将透明质酸酶注射到耳囊中防止一侧半规管形成的动物制剂中进行了实验。单侧第八神经切片显示，在水平线性加速和顺时针/逆时针滚动运动期间上斜眼肌收缩的兴奋完全来自同侧的椭圆囊和后半规管。相反，耳石反应矢量的发育收缩取决于来自对侧后半规管的信号。后面的这些信号抑制了来自垂直于上斜眼肌的椭圆囊部分的方向不正确的分量。这种定向调整符合与眼外运动目标肌肉对齐的空间正确的椭圆囊输入的稳定性。此外，来自对侧的半规管相关连合通路以及同侧前庭核内的局部神经元间抑制回路同时抑制未对准的信号。
Vestibulo-ocular reflexes (VORs) rely on neuronal computations that transform vestibular sensory signals into spatio-temporally appropriate extraocular motor commands. The motoneuronal discharge for contractions of the superior oblique eye muscle during linear translation derives from a utricular epithelial sector that is spatially aligned with the pulling direction of this muscle. In Xenopus laevis, the alignment is gradually achieved during larval development and requires motion-related semicircular canal afferent activity. Here, we studied the origin of semicircular canal and utricular signals responsible for the establishment and maturation of the extraocular motor response vector. Experiments were conducted on semi-intact preparations of Xenopus tadpoles before and after unilateral transection of the VIIIth nerve and in preparations of animals in which semicircular canal formation was prevented on one side by the injection of hyaluronidase into the otic capsule prior to the establishment of the tubular structures. Unilateral VIIIth nerve sections revealed that the excitation underlying the contraction of the superior oblique eye muscle during horizontal linear acceleration and clockwise/counter-clockwise roll motion derives exclusively from the utricle and the posterior semicircular canal on the ipsilateral side. In contrast, the developmental constriction of the otolith response vector depends on signals from the posterior semicircular canal on the contralateral side. These latter signals suppress directionally incorrect components that derive from the utricular sector perpendicular to the superior oblique eye muscle. This directional tuning complies with a stabilization of spatially correct utricular inputs that are aligned with the extraocular motor target muscle. In addition, misaligned signals are concurrently suppressed by semicircular canal-related commissural pathways from the contralateral side and through local interneuronal inhibitory circuits within the ipsilateral vestibular nuclei.
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影响因子：
3.5
作者：
Branoner F;Chagnaud BP;Straka H
通讯作者：
Straka H
影响因子：
2.5
作者：
Goto, F;Straka, H;Dieringer, N
通讯作者：
Dieringer, N
影响因子：
2.5
作者：
BAIRD, RA;SCHUFF, NR
通讯作者：
SCHUFF, NR
影响因子：
2
作者：
MULLER, M
通讯作者：
MULLER, M
DOI：
10.1111/j.1749-6632.1996.tb15711.x
发表时间：
1996-01-01
期刊：
NEW DIRECTIONS IN VESTIBULAR RESEARCH
影响因子：
--
作者：
Angelaki, DE;Hess, BJM
通讯作者：
Hess, BJM