The changing role of the medial preoptic area in the regulation of maternal behavior across the postpartum period: facilitation followed by inhibition.
The changing role of the medial preoptic area in the regulation of maternal behavior across the postpartum period: facilitation followed by inhibition.
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DOI：
10.1016/j.bbr.2009.06.026
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发表时间：
2009-12-14
影响因子：
2.7
通讯作者：
Morrell, Joan I.
中科院分区：
文献类型：
--
作者：
Pereira, Mariana;Morrell, Joan I.
关键词：
大鼠的母性行为经历了相当大的可塑性，平行于幼崽的发育阶段，导致在不同的产后时间点的母性行为和护理的不同模式。下丘脑内侧视前区（mPOA）是大鼠母性行为发生和早期表达的关键神经基质，但其在产后母性行为表达中的具体功能作用尚不清楚。本研究采用可逆的局部神经失活方法来研究mPOA在整个产后期间，特别是延伸到产后后期，一个小检查期间的母亲行为的调节中的作用。这种方法避免了永久性损伤后CNS的代偿性可塑性，并允许对相同个体进行重复测试。在将布比卡因或溶剂输注至mPOA或对照区域后，在雌性大鼠中评价早期（PPD 7 -8）和晚期（PPD 13-14）产后母体行为。正如预期的那样，mPOA失活严重但短暂地破坏了产后早期的母体行为，而输注溶剂或相邻对照部位的失活则没有。然而，在产后后期，短暂的mPOA失活促进了母体行为的表达，与产后晚期的行为表达水平形成了高度对比。结果有力地表明，在整个产后期间，mPOA差异参与协调适当的母体反应与幼犬的发育阶段。
Maternal behavior in rats undergoes considerable plasticity in parallel to the developmental stage of the pups, resulting in distinct patterns of maternal behavior and care at different postpartum time points. The medial preoptic area (mPOA) of the hypothalamus is one critical neural substrate underlying the onset and early expression of maternal behavior in rats but little is known about its specific functional role in the evolving expression of maternal behavior across the postpartum period. The present study uses a reversible local neural inactivation method to examine the role of the mPOA in the regulation of maternal behavior throughout the postpartum period, particularly extending into the late postpartum, a little examined period. This approach avoids the compensatory plasticity in CNS that occurs after permanent lesions, and allows the repeated testing of same individuals. Early (PPD7-8) and late (PPD 13-14) postpartum maternal behavior was evaluated in female rats following infusions of bupivacaine or vehicle into the mPOA or into control areas. As expected, mPOA inactivation severely but transiently disrupted early postpartum maternal behavior whereas infusion of vehicle or inactivation of adjacent control sites did not. Later in the postpartum period, however, transient mPOA inactivation facilitates the expression of maternal behaviors, highly contrasting the behavioral expression levels characteristic of late postpartum. Results strongly demonstrate that the mPOA is differentially engaged throughout postpartum in orchestrating appropriate maternal responses with the developmental stage of the pups.
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影响因子：
2.5
作者：
GROTA, LJ;ADER, R
通讯作者：
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影响因子：
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作者：
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DOI：
10.1590/s0100-879x2000000900015
发表时间：
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